Gene expression changes in rat white adipose tissue after a high-fat diet determined by differential display

被引：45

作者：

López, IP

Milagro, FI

Martí, A

Moreno-Aliaga, MJ

Martínez, JA

De Miguel, C ^{[1
]}

机构：

[1] Univ Navarra, Dept Biochem & Mol Biol, Navarra 31080, Spain

[2] Univ Navarra, Dept Physiol & Nutr LE Nutr & Obes, Navarra 31080, Spain

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 318卷 / 01期

关键词：

differential display; high-fat diet; adipose tissue genes; obesity;

D O I：

10.1016/j.bbrc.2004.04.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The differences in gene expression pattern of visceral white adipose tissue between control and high-fat-fed rats were compared using the mRNA differential display methodology. The results, confirmed by Northern blot, showed eight genes upregulated: adiponectin, fibrillin-1, transferrin, Y-box binding protein-1, IgE receptor beta chain (FcepsilonRIbeta), alpha-1 haemoglobin, and ribosomal proteins S10 and L7 and four genes downregulated: caveolin-2, lactate dehydrogenase-A, mitochondrial 16S rRNA, and mitochondrial cytochrome oxidase subunit I/serine tRNA. Two of these genes have been already related to obesity (adiponectin and caveolin-2) while the others are known to participate in metabolic, signalling or transcription regulation pathways that can be relevant in energy (lipid and/or carbohydrate) metabolism. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：234 / 239

页数：6

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