A precisely controlled DNA biped walking device

被引：438

作者：

Sherman, WB ^{[1
]}

Seeman, NC ^{[1
]}

机构：

[1] NYU, Dept Chem, New York, NY 10003 USA

来源：

NANO LETTERS | 2004年 / 4卷 / 07期

关键词：

D O I：

10.1021/nl049527q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We present an experimental realization of a molecular walking motor built from DNA. The device consists of a biped and a well-defined track where it walks. Input DNA strands act as a convenient interface to allow precise control of the biped walking forward or backward. Psoralen molecules are attached to the ends of the feet in synthesis. When irradiated, the psoralen molecules cross-link strands covalently, allowing unambiguous determination of the state of the walker.

引用

收藏

页码：1203 / 1207

页数：5

相关论文

共 15 条

[1] DNA duplex-quadruplex exchange as the basis for a nanomolecular machine [J].

Alberti, P ;

Mergny, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) :1569-1573

[2] SEQUENCE SPECIFICITY OF PSORALEN PHOTOBINDING TO DNA - A QUANTITATIVE APPROACH [J].

GIA, O ;

MAGNO, SM ;

GARBESI, A ;

COLONNA, FP ;

PALUMBO, M .

BIOCHEMISTRY, 1992, 31 (47) :11818-11822

[3] Molecular motors: structural adaptations to cellular functions [J].

Howard, J .

NATURE, 1997, 389 (6651) :561-567

[4] Construction, analysis, ligation, and self-assembly of DNA triple crossover complexes [J].

LaBean, TH ;

Yan, H ;

Kopatsch, J ;

Liu, FR ;

Winfree, E ;

Reif, JH ;

Seeman, NC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (09) :1848-1860

[5]

Li JWJ, 2002, NANO LETT, V2, P315, DOI [10.1021/nl015713+, 10.1021/n1015713+]

[6] A nanomechanical device based on the B-Z transition of DNA [J].

Mao, CD ;

Sun, WQ ;

Shen, ZY ;

Seeman, NC .

NATURE, 1999, 397 (6715) :144-146

[7] Myosin motors walk the walk [J].

Molloy, JE ;

Veigel, C .

SCIENCE, 2003, 300 (5628) :2045-2046

[8]

Reif J., NATURAL COMPUT, V2, P439

[9] NUCLEIC-ACID JUNCTIONS AND LATTICES [J].

SEEMAN, NC .

JOURNAL OF THEORETICAL BIOLOGY, 1982, 99 (02) :237-247

[10] DENOVO DESIGN OF SEQUENCES FOR NUCLEIC-ACID STRUCTURAL-ENGINEERING [J].

SEEMAN, NC .

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1990, 8 (03) :573-581