Comprehensive Mutation Scanning of LMNA in 268 Patients With Lone Atrial Fibrillation

被引：28

作者：

Brauch, Katharine M. ^{[1
]}

Chen, Lin Y. ^{[4
]}

Olson, Timothy M. ^{[1
,2
,3
]}

机构：

[1] Mayo Clin, Cardiovasc Genet Lab, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Med, Div Cardiovasc Dis, Rochester, MN USA

[3] Mayo Clin, Dept Pediat & Adolescent Med, Div Pediat Cardiol, Coll Med, Rochester, MN USA

[4] Natl Univ Singapore, Div Cardiovasc, Dept Med, Singapore, Singapore

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2009年 / 103卷 / 10期

关键词：

LAMIN A/C GENE; DILATED CARDIOMYOPATHY;

D O I：

10.1016/j.amjcard.2009.01.354

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atrial fibrillation (AF) is a heritable, genetically heterogeneous disorder. To identify gene defects that cause or confer susceptibility to AF, a cohort of 268 unrelated patients with idiopathic forms of familial and sporadic AF was recruited. LMNA, encoding the nuclear membrane proteins, lamin A/C, was selected as a candidate gene for lone AF based on its established association with a syndrome of dilated cardiomyopathy, conduction system disease, and AF. Comprehensive mutation scanning identified only I potentially pathogenic mutation. In conclusion, LMNA mutations rarely cause lone AF and routine genetic testing of LMNA in these patients does not appear warranted. (c) 2009 Elsevier Inc. (Am J Cardiol 2009;103:1426-1428)

引用

页码：1426 / 1428

页数：3

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