Resistance to myocardial ischemia in five rat strains: is there a genetic component of cardioprotection?

被引:53
作者
Baker, JE
Konorev, EA
Gross, GJ
Chilian, WM
Jacob, HJ
机构
[1] Med Coll Wisconsin, Div Pediat Surg, Milwaukee, WI 53226 USA
[2] Med Coll Wisconsin, Biophys Res Inst, Milwaukee, WI 53226 USA
[3] Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA
[4] Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2000年 / 278卷 / 04期
关键词
cardiovascular diseases; genetics;
D O I
10.1152/ajpheart.2000.278.4.H1395
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
There is a need to develop new and more consistent animal models of cardioprotection. Traditionally, outbred dogs, rabbits, and rats have been studied. We determined resistance to ischemia in isolated hearts from inbred strains of rats. Hearts from inbred rats: SS/Mcw (Dahl S, Dahl salt-sensitive), DA/Hsd (Dark Agouti), LEW/Had (Lewis), and BN/SsN/Mcw (Brown Norway); and from an outbred rat: Hsd:WIST (Wistar) were subjected to 27 min of global, no-flow ischemia, followed by 3 h of reperfusion. Infarct size in the Brown Norway rat was 2.5 times less than that observed in the Dahl S rat, with the Dark Agouti, Lewis, and Wister rats intermediate in response. Hearts from Brown Norway rats were also most resistant to ischemia in terms of postischemic enzyme leakage and contractile and vascular function compared with other strains. The average polymorphism rate between strains revealed that such strains were genetically diverse. This study demonstrates strain differences in resistance to myocardial ischemia, suggesting these rats could be used to study a genetic and/or environmental basis for these differences and to provide new animal models for the physiological study of cardioprotection.
引用
收藏
页码:H1395 / H1400
页数:6
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