Thermodynamically-controlled cyclisation and interconversion of oligocholates: metal ion templated 'living' macrolactonisation

被引：93

作者：

Brady, PA ^{[1
]}

Sanders, JKM ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,CHEM LAB,CAMBRIDGE CTR MOL RECOGNIT,CAMBRIDGE CB2 1EW,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1997年 / 21期

关键词：

D O I：

10.1039/a703390g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of ester-linked macrocyclic oligomers (dimer-pentamer) of cholates equipped with a variety of recognition and reporter elements has been prepared(a)by conventional irreversible chemistry, and (b) using methoxide-catalysed transesterification under reversible equilibrium conditions. Templating by metal ions under these equilibrium conditions is also demonstrated. These results demonstrate the feasibility of creating a dynamic combinatorial library of receptors.

引用

页码：3237 / 3253

页数：17

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