Lecithin promotes adipocyte differentiation and hepatic lipid accumulation

被引：19

作者：

Zhang, Yuebo ^{[1
]}

Huang, Cheng ^{[1
]}

Sheng, Xiaoyan ^{[1
]}

Gong, Zhenwei ^{[1
]}

Zang, Ying Qin ^{[1
]}

机构：

[1] Chinese Acad Sci, Grad Sch CAS, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2009年 / 23卷 / 04期

关键词：

lecithin; adipocyte differentiation; hepatic lipid deposit; PPAR-GAMMA; CHOLESTEROL ACYLTRANSFERASE; LIPOPROTEIN OXIDATION; GENE-EXPRESSION; ADIPOGENESIS; LIGAND; PPAR-GAMMA-2; STEATOSIS; CHOLINE;

D O I：

10.3892/ijmm_00000150

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Lecithin is an essential biological component and widely used as a nutritional supplement for protecting cells from oxidation, increase fat burning and preventing cardiovascular disease. Lecithin contains fatty acids identified as the peroxisome proliferator-activated receptor (PPAR) agonists, However, the role of lecithin in adipogenesis and lipogenesis remains elusive. 3T3-L1 cells and mouse primary preadipocytes were used to characterize the properties of lecithin related to adipogenesis and lipogenesis. We found that lecithin promoted adipocyte differentiation and differentiation-specific gene expression, and increased triglycerides and free fatty acid levels in the adipocytes. These effects are independent of the clonal expansion of 3T3-L1 cells and the upstream PPAR gamma regulator, CCAAT-enhancer-binding protein ss. Furthermore, lecithin induced lipid accumulation in human hepatoma HepG2 cells. Our data suggest that lecithin is involved in adipogenesis, lipogenesis and hepatic lipid accumulation and it is implicated in obesity and hepatic steatosis.

引用

页码：449 / 454

页数：6

共 24 条

[1]

PPARγ is required for placental, cardiac, and adipose tissue development [J].