Antioxidant and Anticholinesterase Activity Evaluation of ent-Kaurane Diterpenoids from Sideritis arguta

被引：55

作者：

Ertas, Abduelselam ^{[2
]}

Ozturk, Mehmet ^{[3
]}

Boga, Mehmet ^{[2
]}

Topcu, Guelacti ^{[1
]}

机构：

[1] Istanbul Tech Univ, Fac Sci & Letters, Dept Chem, TR-34469 Istanbul, Turkey

[2] Istanbul Univ, Dept Analyt Chem, Fac Pharm, TR-34116 Istanbul, Turkey

[3] Mugla Univ, Dept Chem, Fac Arts & Sci, TR-48121 Mugla, Turkey

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 03期

关键词：

SPANISH LABIATAE; CONSTITUENTS; COMPONENTS; LAMIACEAE;

D O I：

10.1021/np800671p

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The petroleum ether and acetone extracts of the aerial parts of Sideritis arguta afforded two new and six known diterpenoids with the ent-kaurane skeleton. The structures of the new diterpenoids were determined as ent-7 alpha,18-diacetoxy-16 beta-hydroxykaurane (diacetyidistanol) (1) and ent-7 alpha-acetoxy,15 alpha,18-dihydroxykaur-16-ene (15-epi-eubol) (2) by spectroscopic data interpretation. Antioxidant potential was investigated for the ent-kauranes and the plant extracts by three methods (beta-carotene bleaching, free-radical scavenging, and superoxide-anion scavenging activity). Acetylcholinesterase and butyrylcholinesterase inhibitory activity were also evaluated, and the ent-kauranes eubol (3), sideroxol (5), and 7-epi-candicandiol (6) exhibited moderate butyrylcholinesterase inhibitory activity.

引用

页码：500 / 502

页数：3

共 25 条

[1]

Armata A, 2008, FOOD CHEM, V111, P179, DOI [10.1016/j.foodchem.2008.03,061, 10.1016/j.foodchem.2008.03.061]

[2]

Toxicity of acetone extract of Sideritis trojana and 7-epicandicandiol, 7-epic andicandiol diacetate and 18-acetylsideroxol against stored pests Acanthoscelides obtectus (Say), Sitophilus granarius (L.) and Ephestia kuehniella (Zell.) [J].

Aslan, I ;

Kiliç, T ;

Gören, AC ;

Topçu, G .

INDUSTRIAL CROPS AND PRODUCTS, 2006, 23 (02) :171-176

[3]

Bioactive natural products as a potential source of new pharmacophores. A theory of memory [J].

Atta-ur-Rahman ;

Choudhary, MI .

PURE AND APPLIED CHEMISTRY, 2001, 73 (03) :555-560

[4]

ANTIOXIDANT DETERMINATIONS BY THE USE OF A STABLE FREE RADICAL [J].

BLOIS, MS .

NATURE, 1958, 181 (4617) :1199-1200

[5]

de Castro C.O., 1994, A Taxonomic Revision of the Section Sideritis (Genus Sideritis) (Labiatae)

[6]

Duman H., 2000, Flora of Turkey and East Aegean Islands (Supplement 2), VVolume 11, P201

[7]

A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY [J].

ELLMAN, GL ;

COURTNEY, KD ;

ANDRES, V ;

FEATHERSTONE, RM .

BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) :88-&

[8]

DITERPENES FROM SIDERITIS-FERRENSIS [J].

FRAGA, BM ;

HERNANDEZ, MG ;

SANTANA, JMH ;

ARTEAGA, JM .

PHYTOCHEMISTRY, 1991, 30 (03) :913-915

[9]

TERPENOID COMPONENTS OF SPANISH LABIATAE .15. DITERPENOIDS FROM SIDERITIS-PUSILLA SUBSP FLAVOVIRENS [J].

GARCIAGRANADOS, A ;

MARTINEZ, A ;

ONORATO, ME ;

SOCORRO, O .

PHYTOCHEMISTRY, 1984, 23 (03) :607-610

[10]

TERPENIC COMPONENTS OF SPANISH LABIATAE .20. DITERPENOIDS FROM SIDERITIS-ARBORESCENS SUBSP PAULII [J].

GARCIAGRANADOS, A ;

MARTINEZ, A ;

ONORATO, ME .

PHYTOCHEMISTRY, 1985, 24 (03) :517-521

← 1 2 3 →