In vivo 31P-MRS assessment of muscle-pH, cytolsolic-[Mg2+] and phosphorylation potential after supplementing hypokaliuric renal stone patients with potassium and magnesium salts

被引:3
作者
Mairiang, E [1 ]
Hanpanich, P
Sriboonlue, P
机构
[1] Khon Kaen Univ, Fac Med, Dept Radiol, Khon Kaen 40002, Thailand
[2] Khon Kaen Univ, Fac Med, Dept Biochem, Khon Kaen 40002, Thailand
关键词
P-31-MRS; renal stone; potassium; magnesium; intracellular-pH;
D O I
10.1016/j.mri.2004.01.038
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Renal stone patients in rural northeast Thailand have a low potassium and magnesium status and low urinary excretion of citrate. We measured the changes of urinary citrate excretion and assessed in vivo skeletal muscle metabolism for intracellular-pH, cytosolic-[Mg2+] and phosphorylation potential (using the phosphorus magnetic resonance spectroscopy P-31-MRS) after oral supplementation to hypokaliuric renal stone patients with oral potassium and magnesium salts. The patients comprised four groups: Group 1 (n = 10) control, Group 2 (n = 3), Group 3 (n = 5) and Group 4 (n = 6) supplemented for a month with potassium citrate, potassium citrate plus amino acid chelated magnesium. and potassium-magnesium citrate, respectively. Though urinary citrate excretion was increased in all three supplemented groups, the increases in intracellular-pH, cytosolic-[Mg2+] and phosphocreatine (PCr)/beta-ATP were prominent only in Group 3. The increase in PCr/beta-ATP was also observed in Group 4. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:715 / 719
页数:5
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