Concise asymmetric synthesis of dysidiolide

被引：36

作者：

Takahashi, M

Dodo, K

Hashimoto, Y

Shirai, R

机构：

[1] Nara Inst Sci & Technol, Res & Educ Ctr Mat Sci, Nara 6300101, Japan

[2] Univ Tokyo, IMCB, Bunkyo Ku, Tokyo 1130032, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 13期

关键词：

terpene; anti-cancer agent; asymmetric synthesis; Diels-Alder reaction; alkylation;

D O I：

10.1016/S0040-4039(00)00078-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cdc25A protein phosphatase inhibitor dysidiolide (1) has been synthesized via intermolecular Diels-Alder reaction of the triene 4 with crotonaldehyde and construction of a quaternary carbon center by methylation of the exocyclic enolate. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：2111 / 2114

页数：4

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