Effect of ertapenem protein binding on killing of bacteria

被引：38

作者：

Nix, DE ^{[1
]}

Matthias, KR ^{[1
]}

Ferguson, EC ^{[1
]}

机构：

[1] Univ Arizona, Coll Pharm, Dept Pharm Practice & Sci, Tucson, AZ 85721 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 09期

关键词：

D O I：

10.1128/AAC.48.9.3419-3424.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The effect of protein binding on the antimicrobial activity of ertapenem was evaluated using the bacterial kill rate and concentration-response studies. Various proportions of human serum were utilized to determine the total and free-drug concentrations using a validated high-performance liquid chromatography assay. The MICs and kill curves were determined for test isolates of Enterobacter cloacae and Staphylococcus aureus at various percentages of human serum. The killing of bacteria was analyzed in relation to the free and total concentrations of ertapenem at various proportions of human serum. It was determined that unbound ertapenem was responsible for the antimicrobial activity against the test isolates.

引用

页码：3419 / 3424

页数：6

共 20 条

[1] COMPARATIVE EFFECT OF PROTEIN-BINDING ON THE KILLING ACTIVITIES OF TEICOPLANIN AND VANCOMYCIN [J].

BAILEY, EM ;

RYBAK, MJ ;

KAATZ, GW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (06) :1089-1092

[2]

Craig W A, 1989, Infect Dis Clin North Am, V3, P407

[3] Basic pharmacodynamics of antibacterials with clinical applications to the use of β-lactams, glycopeptides, and linezolid [J].

Craig, WA .

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, 2003, 17 (03) :479-+

[4]

CRAIG WA, 1996, ANTIBIOTICS LAB MED, P477

[5] CORRELATION OF PREDICTED SERUM BACTERICIDAL ACTIVITIES AND VALUES MEASURED IN VOLUNTEERS [J].

DRUSANO, G ;

STANDIFORD, H ;

RYAN, P ;

MCNAMEE, W ;

TATEM, B ;

SCHIMPFF, S .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1986, 5 (01) :88-92

[6] SIGNIFICANCE OF EXTRAVASCULAR PROTEIN-BINDING FOR ANTIMICROBIAL PHARMACODYNAMICS IN AN INVITRO CAPILLARY MODEL OF INFECTION [J].

DUDLEY, MN ;

BLASER, J ;

GILBERT, D ;

ZINNER, SH .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (01) :98-101

[7] ANTIMICROBIAL ACTIVITY OF CEFTRIAXONE, CEFOTAXIME, DESACETYLCEFOTAXIME, AND CEFOTAXIME-DESACETYLCEFOTAXIME IN THE PRESENCE OF HUMAN-SERUM [J].

JONES, RN ;

BARRY, AL .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (05) :818-820

[8]

KUNUN CM, 1965, CLIN PHARMACOL THER, V7, P166

[9] EFFECT OF PROTEIN-BINDING ON SERUM BACTERICIDAL ACTIVITIES OF CEFTAZIDIME AND CEFOPERAZONE IN HEALTHY-VOLUNTEERS [J].

LAM, YWF ;

DUROUX, MH ;

GAMBERTOGLIO, JG ;

BARRIERE, SL ;

GUGLIELMO, BJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (03) :298-302

[10]

LANG SDR, 1981, DRUGS, V22, P52, DOI 10.2165/00003495-198100221-00012

← 1 2 →