Elevated levels of serum interleukin-1 beta in combat-related posttraumatic stress disorder

被引：158

作者：

Spivak, B

Shohat, B

Mester, R

Avraham, S

GilAd, I

Bleich, A

Valevski, A

Weizman, A

机构：

[1] BEILINSON MED CTR,GEHA PSYCHIAT HOSP,IL-49100 PETAH TIQWA,ISRAEL

[2] NESS ZIONA MED HLTH CTR,RES UNIT,NESS ZIONA,ISRAEL

[3] TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL

[4] BEILINSON MED CTR,CLIN IMMUNOL LAB,IL-49100 PETAH TIQWA,ISRAEL

[5] ISRAEL DEF FORCES MED CORPS,PSYCHIAT SERV,TEL HASHOMER,ISRAEL

[6] FELSENSTEIN MED RES CTR,LAB BIOL PSYCHIAT,PETAH TIQWA,ISRAEL

[7] TEL AVIV SOURASKI MED CTR,PSYCHIAT OUTPATIENT CLIN,TEL AVIV,ISRAEL

来源：

BIOLOGICAL PSYCHIATRY | 1997年 / 42卷 / 05期

关键词：

posttraumatic stress disorder; interleukin-1; beta; soluble interleukin-2 receptor; cortisol;

D O I：

10.1016/S0006-3223(96)00375-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Levels of serum interleukin-1 beta (IL-1 beta) and soluble interleukin-2 receptor (slL-2R) were assessed in 19 male patients with combat-related posttraumatic stress disorder (PTSD) in comparison to 19 age-and sex-matched healthy volunteers, Serum IL-1 beta levels (but not slL-2R) were significantly higher (p < .001) in the PTSD patients than in the controls. IL-1 beta levels did not correlate with cortisol levels, severity of PTSD, anxiety, depressive symptoms, or alexithymia score; however, they did correlate significantly (r = .54, p < .005) with the duration of PTSD symptoms. It is possible that desensitization of the hypothalamic-pituitary-axis in chronic PTSD patients counteracts the stimulatory effect of IL-1 beta on cortisol secretion. (C) 1997 Society of Biological Psychiatry.

引用

页码：345 / 348

页数：4

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[1] THE IMMUNE SYSTEM - OUR MOBILE BRAIN [J].