A new 3,4-seco-labdane diterpenoid with inhibitory activity against the production of nitric oxide from the leaves of Callicarpa nudiflora

被引：43

作者：

Zhang, Lei ^{[1
]}

Liu, Ming-Sheng ^{[2
]}

Huang, Jian ^{[1
]}

Li, Guo-Yu ^{[3
]}

Zhang, Cui ^{[1
]}

Dong, Lin ^{[4
]}

Zhang, Ke ^{[3
]}

Wang, Jin-Hui ^{[1
,3
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[2] Acad South Med & Li Med Hainan Prov, Haikou 571199, Peoples R China

[3] Shihezi Univ, Sch Pharm, Shihezi 832023, Peoples R China

[4] Hainan Med Coll, Hainan Prov Key Lab R&D Trop Med Plants, Haikou 571199, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2014年 / 16卷 / 02期

关键词：

ENT-3,4-SECO-LABDANE;

D O I：

10.1080/10286020.2013.841675

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

A new 3,4-seco-labdane diterpenoid, 3,4-seco-12R,13S-dihydroxy-4(18),8(17), 14(15)-labdatrien-3-oic acid (1), was isolated from the leaves of Callicarpa nudiflora. The structure of 1 was elucidated by 1D NMR, 2D NMR and HRESIMS data, and confirmed by single-crystal X-ray diffraction analysis. 3,4-seco-12R,13S-Dihydroxy-4(18),8(17),14(15)-labdatrien-3-oic acid (1) exerted inhibitory activity against the production of nitric oxide in RAW264.7 stimulated by lipopolysaccharide. © 2013 Taylor & Francis.

引用

页码：216 / 221

页数：6

共 11 条

[1]

Cai JinPing Cai JinPing, 2012, Drugs and Clinic, V27, P60

[2]

Two new ent-3,4-seco-labdane diterpenoids from Callicarpa nudiflora [J].