A microsatellite polymorphism (tttta)n in the promoter of the CYP11a gene in Chinese women with polycystic ovary syndrome

被引：55

作者：

Wang, Yong

Wu, Xiaoke ^{[1
]}

Cao, Yunxia

Yi, Long

Chen, Jianxiu

机构：

[1] Heilongjiang Univ Chinese Med, Dept Obstet & Gynecol, Affiliated Hosp, Harbin 150040, Peoples R China

[2] Nanjing Univ, Human Genet Identificat Lab, Sch Med, Nanjing 210008, Peoples R China

[3] Anhui Med Univ, Dept Obstet & Gynecol, Hefei, Peoples R China

[4] Nanjing Univ, Sch Life Sci, Nanjing 210008, Peoples R China

来源：

FERTILITY AND STERILITY | 2006年 / 86卷 / 01期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/j.fertnstert.2005.12.037

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

A (tttta)n microsatellite polymorphism in the promoter of CYP11a gene was investigated in 201 Chinese Han women with polycystic ovary syndrome (PCOS) and 147 control women. The 6/6 genotype was defined with significant difference of CYP11a polymorphism between women with PCOS and control women, and associated with greater BMI in PCOS patients, suggesting a certain role of the six-repeat allele variant in the pathogenesis of Chinese women with PCOS.

引用

收藏

页码：223 / 226

页数：4

相关论文

共 16 条

[1]

[Anonymous], 1992, POLYCYSTIC OVARY SYN

[2] Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome [J].

Chang, J ;

Azziz, R ;

Legro, R ;

Dewailly, D ;

Franks, S ;

Tarlatzis, BC ;

Fauser, B ;

Balen, A ;

Bouchard, P ;

Dahlgren, E ;

Devoto, L ;

Diamanti, E ;

Dunaif, A ;

Filicori, M ;

Homburg, R ;

Ibanez, L ;

Laven, J ;

Magoffin, D ;

Nestler, J ;

Norman, RJ ;

Pasquali, R ;

Pugeat, M ;

Strauss, J ;

Tan, S ;

Taylor, A ;

Wild, R ;

Wild, S ;

Ehrmann, D ;

Lobo, R .

FERTILITY AND STERILITY, 2004, 81 (01) :19-25

[3] Overexpression of theca-cell messenger RNA in polycystic ovary syndrome does not correlate with polymorphisms in the cholesterol side-chain cleavage and 17α-hydroxylase/C17-20 lyase promoters [J].

Daneshmand, S ;

Weitsman, SR ;

Navab, A ;

Jakimiuk, AJ ;

Magoffin, DA .

FERTILITY AND STERILITY, 2002, 77 (02) :274-280

[4] Microsatellite polymorphism (tttta)n at-528 base pairs of gene CYP11α influences hyperandrogenemia in patients with polycystic ovary syndrome [J].

Diamanti-Kandarakis, E ;

Bartzis, MI ;

Bergiele, AT ;

Tsianateli, TC ;

Kouli, CR .

FERTILITY AND STERILITY, 2000, 73 (04) :735-741

[5] POLYCYSTIC-OVARY-SYNDROME AS A FORM OF FUNCTIONAL OVARIAN HYPERANDROGENISM DUE TO DYSREGULATION OF ANDROGEN SECRETION [J].

EHRMANN, DA ;

BARNES, RB ;

ROSENFIELD, RL .

ENDOCRINE REVIEWS, 1995, 16 (03) :322-353

[6] THE UBIQUITOUS POLYCYSTIC OVARY - COMMENT [J].

FRANKS, S .

JOURNAL OF ENDOCRINOLOGY, 1991, 129 (03) :317-319

[7]

GAASENBEEK M, J CLIN ENDOCRINOL ME, V89, P2408

[8] Association of the steroid synthesis gene CYP11a with polycystic ovary syndrome and hyperandrogenism [J].

Gharani, N ;

Waterworth, DM ;

Batty, S ;

White, D ;

GillingSmith, C ;

Conway, GS ;

McCarthy, M ;

Franks, S ;

Williamson, R .

HUMAN MOLECULAR GENETICS, 1997, 6 (03) :397-402

[9] HYPERSECRETION OF ANDROSTENEDIONE BY ISOLATED THECAL CELLS FROM POLYCYSTIC OVARIES [J].

GILLINGSMITH, C ;

WILLIS, DS ;

BEARD, RW ;

FRANKS, S .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 79 (04) :1158-1165

[10] Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome [J].

Legro, RS ;

Driscoll, D ;

Strauss, JF ;

Fox, J ;

Dunaif, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14956-14960