High levels of urinary vascular endothelial growth factor in women with severe preeclampsia

被引:11
作者
Roes, EM
Steegers, EAP
Thomas, CMG
Geurts-Moespot, A
Raijmakers, MTM
Peters, WHM
Sweep, CGJ [1 ]
机构
[1] Univ Nijmegen, Ctr Med, Dept Obstet & Gynecol, Nijmegen, Netherlands
[2] Univ Nijmegen, Ctr Med, Dept Chem Endocrinol, Nijmegen, Netherlands
[3] Univ Nijmegen, Ctr Med, Dept Gastroenterol, Nijmegen, Netherlands
[4] Erasmus Univ, Med Ctr, Dept Obstet & Gynecol, Rotterdam, Netherlands
关键词
preeclampsia; urinary; VEGF;
D O I
10.1177/172460080401900110
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Elevated plasma VEGF concentrations in preeclampsia are associated with local placental ischemia and endothelial dysfunction. We investigated the urinary VEGF excretion in women with severe preeclampsia (n=37) and its relation with proteinuria compared to that in healthy pregnant (n=32) and non-pregnant women (n=30). In women with severe preeclampsia VEGF levels were 54.0 (19.9-192.4) ng/mmol creatinine, significantly (p<0.0001) higher than levels in pregnant controls (28.2 (6.7-63.0) ng/mmol creatinine) and non-pregnant controls (29.5 (10.1-59.1) ng/mmol creatinine). Proteinuria was not significantly correlated with urinary VEGF levels. in conclusion, high urinary VEGF concentrations in severe preeclampsia might reflect increased renal production of VEGF rather than elevated VEGF levels in the systemic circulation.
引用
收藏
页码:72 / 75
页数:4
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