Ginsenoside Re attenuate β-amyloid and serum-free induced neurotoxicity in PC12 cells

被引：43

作者：

Ji, Z. N. ^{[1
]}

Dong, T. T. X.

Ye, W. C.

Choi, R. C.

Lo, C. K.

Tsim, K. W. K.

机构：

[1] Yijishan Hosp, Wannan Med Coll, Dept Oncol, Wuhu 241001, Anhui, Peoples R China

[2] Hong Kong Univ Sci & Technol, Dept Biol, Hong Kong, Hong Kong, Peoples R China

[3] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510630, Peoples R China

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2006年 / 107卷 / 01期

关键词：

ginsenoside Re; PC; 12; cells; Serum-free medium; beta-amyloid peptide; neuroprotection;

D O I：

10.1016/j.jep.2006.02.004

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Aim: To study the effect of ginsenoside Re on PC12 cell damage induced by serum deprivation and P-amyloid peptide. Methods: PC 12 cell survival was measured by MT7 and lactate dehydrogenase (LDH) assay. Results Serum-free medium and P-amyloid peptide (10-100 mu M) induced cytotoxicity in PC 12 cells. Ginsenoside Re (0.1-100 mu M) attenuated the cytotoxic effects of serum-free medium and beta-amyloid peptide (50 mu M) in a concentration-dependent manner. Conclusion: Ginsenoside Re prevented PC 12 cells from lesion induced by serum-free medium and P-amyloid peptide. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：48 / 52

页数：5

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