Differentially Expressed MicroRNAs in Meningiomas Grades I and II Suggest Shared Biomarkers with Malignant Tumors

被引:29
作者
El-Gewely, Mohamed Raafat [1 ]
Andreassen, Morten [1 ]
Walquist, Mari [1 ,9 ]
Ursvik, Anita [1 ]
Knutsen, Erik [1 ]
Nystad, Mona [2 ,3 ,4 ]
Coucheron, Dag H. [1 ]
Myrmel, Kristin Smistad [5 ,7 ]
Hennig, Rune [6 ]
Johansen, Steinar D. [1 ,8 ]
机构
[1] UiT Arctic Univ Norway, Fac Hlth Sci, Dept Med Biol, N-9037 Tromso, Norway
[2] UiT Arctic Univ Norway, Fac Hlth Sci, Womens Hlth & Perinatol Res Grp, Dept Clin Med, N-9037 Tromso, Norway
[3] Univ Hosp North Norway, Dept Obstet & Gynecol, N-9038 Tromso, Norway
[4] Univ Hosp North Norway, Dept Med Genet, Div Child & Adolescent Hlth, N-9038 Tromso, Norway
[5] Univ Hosp North Norway, Dept Pathol, N-9038 Tromso, Norway
[6] Univ Hosp North Norway, Dept Neurosurg, N-9038 Tromso, Norway
[7] UiT Arctic Univ Norway, Dept Clin Med, Fac Hlth Sci, Div Neurosurgery, N-9037 Tromso, Norway
[8] Nord Univ, Marine Genom Grp, Fac Biosciences & Aquaculture, Bodo, Norway
[9] UiT Arctic Univ Norway, Fac Biosci Fisheries & Econ, Norwegian Coll Fishery Sci, Grp Seafood Sci, N-9037 Tromso, Norway
关键词
meningioma; SOLiD deep sequencing; miRNA; RT-qPCR; cap cells and Immunohistochemistry (IHC); E-CADHERIN; MESENCHYMAL TRANSITION; PROGNOSTIC BIOMARKER; CELL-PROLIFERATION; PROSTATE-CANCER; GROWTH; PATHWAYS; TARGETS; IDENTIFICATION; INVOLVEMENT;
D O I
10.3390/cancers8030031
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
Meningiomas represent the most common primary tumors of the central nervous system, but few microRNA (miRNA) profiling studies have been reported so far. Deep sequencing of small RNA libraries generated from two human meningioma biopsies WHO grades I (benign) and II (atypical) were compared to excess dura controls. Nineteen differentially expressed miRNAs were validated by RT-qPCR using tumor RNA from 15 patients and 5 meninges controls. Tumor suppressor miR-218 and miR-34a were upregulated relative to normal controls, however, miR-143, miR-193b, miR-451 and oncogenic miR-21 were all downregulated. From 10 selected putative mRNA targets tested by RT-qPCR only four were differentially expressed relative to normal controls. PTEN and E-cadherin (CDH1) were upregulated, but RUNX1T1 was downregulated. Proliferation biomarker p63 was upregulated with nuclear localization, but not detected in most normal arachnoid tissues. Immunoreactivity of E-cadherin was detected in the outermost layer of normal arachnoids, but was expressed throughout the tumors. Nuclear Cyclin D1 expression was positive in all studied meningiomas, while its expression in arachnoid was limited to a few trabecular cells. Meningiomas of grades I and II appear to share biomarkers with malignant tumors, but with some additional tumor suppressor biomarkers expression. Validation in more patients is of importance.
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页数:18
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