The role of pneumolysin in the pathogenesis of Streptococcus pneumoniae infection

被引：42

作者：

Cockeran, R ^{[1
]}

Anderson, R ^{[1
]}

Feldman, C ^{[1
]}

机构：

[1] Univ Pretoria, Dept Immunol, Fac Hlth Sci, Med Res Council Unit Inflammat & Immun, ZA-0001 Pretoria, South Africa

来源：

CURRENT OPINION IN INFECTIOUS DISEASES | 2002年 / 15卷 / 03期

关键词：

D O I：

10.1097/00001432-200206000-00004

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In addition to being cytotoxic for eukaryotic cells, recent research has clearly indicated that pneumolysin at sub-cytolytic concentrations potentiates the proinflammatory activities of neutrophils and macrophages. Together these cytotoxic and proinflammatory activities of the toxin are likely to contribute to the virulence of the pneumococcus, particularly in facilitating adherence, invasion and dissemination of this important microbial pathogen. Pneumolysin-based vaccine strategies, although in the early stages of development and evaluation, show promise in reducing the severity of pneumococcal disease.

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页码：235 / 239

页数：5

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