The Contribution of Different Components in QiShenYiQi Pills® to Its Potential to Modulate Energy Metabolism in Protection of Ischemic Myocardial Injury

被引：20

作者：

Cui, Yuan-Chen ^{[1
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Yan, Li ^{[1
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Pan, Chun-Shui ^{[1
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Hu, Bai-He ^{[1
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Chang, Xin ^{[1
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,3
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Fan, Jing-Yu ^{[1
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Han, Jing-Yan ^{[1
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]}

机构：

[1] Peking Univ, Hlth Sci Ctr, Tasty Microcirculat Res Ctr, Beijing, Peoples R China

[2] State Adm Tradit Chinese Med Peoples Republ China, Key Lab Microcirculat, Beijing, Peoples R China

[3] State Adm Tradit Chinese Med Peoples Republ China, Key Lab Stasis & Phlegm, Beijing, Peoples R China

[4] Beijing Lab Integrat Microangiopathy, Beijing, Peoples R China

[5] State Key Lab Core Technol Innovat Chinese Med, Beijing, Peoples R China

[6] Peking Univ, Sch Basic Med Sci, Dept Intergrat Chinese & Western Med, Beijing, Peoples R China

来源：

FRONTIERS IN PHYSIOLOGY | 2018年 / 9卷

基金：

中国国家自然科学基金;

关键词：

ischemic heart disease; ATP synthesis; cardiac structure; F-actin; energy metabolism; REPERFUSION INJURY; GINSENOSIDE RB1; COLITIS; RG1;

D O I：

10.3389/fphys.2018.00389

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

Ischemic heart diseases remain a challenge for clinicians. QiShenYiQi pills (R) (QSYQ) has been reported to be curative during coronary heart diseases with modulation of energy metabolism as one of the underlying mechanisms. In this study, we detected the effect of QSYQ and its components on rat myocardial structure, mitochondrial respiratory chain complexes activity and energy metabolism, and heart function after 30 min of cardiac ischemia, with focusing on the contribution of each component to its potential to regulate energy metabolism. Results showed that treatment with QSYQ and all its five components protected myocardial structure from damage by ischemia. QSYQ also attenuated release of myocardial cTnI, and restored the production of ATP after cardiac ischemia. AS-IV and Rb1, but not Rg1, R1, and DLA, had similar effect as QSYQ in regulation of energy metabolism. These results indicate that QSYQ may prevent ischemia-induced cardiac injury via regulation of energy metabolism, to which each of its components contributes differently.

引用

页数：9

共 25 条

[1]

REDUCTION IN EXPERIMENTAL INFARCT SIZE BY RECOMBINANT HUMAN SUPEROXIDE-DISMUTASE - INSIGHTS INTO THE PATHOPHYSIOLOGY OF REPERFUSION INJURY [J].