Aurora A kinase activates YAP signaling in triple-negative breast cancer

被引：55

作者：

Chang, S-S ^{[1
,2
]}

Yamaguchi, H. ^{[1
]}

Xia, W. ^{[1
]}

Lim, S-O ^{[1
]}

Khotskaya, Y. ^{[3
]}

Wu, Y. ^{[4
]}

Chang, W-C ^{[5
]}

Liu, Q. ^{[6
,7
]}

Hung, M-C ^{[1
,2
,5
,8
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, 1515 Holcombe Blvd,Unit 108, Houston, TX 77030 USA

[2] Univ Texas Houston, Grad Sch Biomed Sci Houston, Canc Biol Program, Houston, TX USA

[3] Univ Texas Houston, MD Anderson Canc Ctr, Sheikh Khalifa Bin Zayed Nahyan Inst Personalized, Houston, TX USA

[4] Univ Texas Houston, MD Anderson Canc Ctr, Dept Breast Med Oncol, Houston, TX USA

[5] China Med Univ, Ctr Mol Med, Taichung, Taiwan

[6] Sun Yat Sen Univ, Ctr Canc, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou, Peoples R China

[7] Dalian Med Univ, First Affiliated Hosp, Collaborat Innovat Ctr Onco, Inst Canc Stem Cell, Dalian, Peoples R China

[8] Asia Univ, Dept Biotechnol, Taichung, Taiwan

来源：

ONCOGENE | 2017年 / 36卷 / 09期

基金：

美国国家卫生研究院;

关键词：

TO-MESENCHYMAL TRANSITION; HIPPO PATHWAY; CELL-MIGRATION; PROTEIN; PHOSPHORYLATION; KIBRA; COMPLEX; CHEMORESISTANCE; REGULATOR; TAZ;

D O I：

10.1038/onc.2016.292

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The Yes-associated protein (YAP) is an effector that transduces the output of the Hippo pathway to transcriptional modulation. Considering the role of YAP in cancers, this protein has emerged as a key node in malignancy development. In this study, we determined that Aurora A kinase acts as a positive regulator for YAP-mediated transcriptional machinery. Specifically, YAP associates with Aurora A predominantly in the nucleus. Activation of Aurora A can impinge on YAP activity through direct phosphorylation. Moreover, aberrant expression of YAP and Aurora A signaling is highly correlated with triple-negative breast cancer (TNBC). We herein provide evidence to establish the functional relevance of this newly discovered regulatory axis in TNBC.

引用

页码：1265 / 1275

页数：11

共 57 条

[1]

The WW Domain Protein Kibra Acts Upstream of Hippo in Drosophila [J].

Baumgartner, Roland ;

Poernbacher, Ingrid ;

Buser, Nathalie ;

Hafen, Ernst ;

Stocker, Hugo .

DEVELOPMENTAL CELL, 2010, 18 (02) :309-316

[2]

Structural basis of Aurora-A activation by TPX2 at the mitotic spindle [J].

Bayliss, R ;

Sardon, T ;

Vernos, I ;

Conti, E .

MOLECULAR CELL, 2003, 12 (04) :851-862

[3]

YAP1 increases organ size and expands undifferentiated progenitor cells [J].

Camargo, Fernando D. ;

Gokhale, Sumita ;

Johnnidis, Jonathan B. ;

Fu, Dongdong ;

Bell, George W. ;

Jaenisch, Rudolf ;

Brummelkamp, Thijn R. .

CURRENT BIOLOGY, 2007, 17 (23) :2054-2060

[4]

Aurora-A Is Essential for the Tumorigenic Capacity and Chemoresistance of Colorectal Cancer Stem Cells [J].

Cammareri, Patrizia ;

Scopelliti, Alessandro ;

Todaro, Matilde ;

Eterno, Vincenzo ;

Francescangeli, Federica ;

Moyer, Mary Pat ;

Agrusa, Antonino ;

Dieli, Francesco ;

Zeuner, Ann ;

Stassi, Giorgio .

CANCER RESEARCH, 2010, 70 (11) :4655-4665

[5]

Homeodomain-Interacting Protein Kinase Regulates Yorkie Activity to Promote Tissue Growth [J].

Chen, Joanna ;

Verheyen, Esther M. .

CURRENT BIOLOGY, 2012, 22 (17) :1582-1586

[6]

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells [J].

Cordenonsi, Michelangelo ;

Zanconato, Francesca ;

Azzolin, Luca ;

Forcato, Mattia ;

Rosato, Antonio ;

Frasson, Chiara ;

Inui, Masafumi ;

Montagner, Marco ;

Parenti, Anna R. ;

Poletti, Alessandro ;

Daidone, Maria Grazia ;

Dupont, Sirio ;

Basso, Giuseppe ;

Bicciato, Silvio ;

Piccolo, Stefano .

CELL, 2011, 147 (04) :759-772

[7]

The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα+ breast cancer cells [J].

D'Assoro, A. B. ;

Liu, T. ;

Quatraro, C. ;

Amato, A. ;

Opyrchal, M. ;

Leontovich, A. ;

Ikeda, Y. ;

Ohmine, S. ;

Lingle, W. ;

Suman, V. ;

Ecsedy, J. ;

Iankov, I. ;

Di Leonardo, A. ;

Ayers-Ringler, J. ;

Degnim, A. ;

Billadeau, D. ;

McCubrey, J. ;

Ingle, J. ;

Salisbury, J. L. ;

Galanis, E. .

ONCOGENE, 2014, 33 (05) :599-610

[8]

Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion [J].

Do, T-V ;

Xiao, F. ;

Bickel, L. E. ;

Klein-Szanto, A. J. ;

Pathak, H. B. ;

Hua, X. ;

Howe, C. ;

O'Brien, S. W. ;

Maglaty, M. ;

Ecsedy, J. A. ;

Litwin, S. ;

Golemis, E. A. ;

Schilder, R. J. ;

Godwin, A. K. ;

Connolly, D. C. .

ONCOGENE, 2014, 33 (05) :539-549

[9]

Elucidation of a universal size-control mechanism in Drosophila and mammals [J].

Dong, Jixin ;

Feldmann, Georg ;

Huang, Jianbin ;

Wu, Shian ;

Zhang, Nailing ;

Comerford, Sarah A. ;

Gayyed, Mariana F. ;

Anders, Robert A. ;

Maitra, Anirban ;

Pan, Duojia .

CELL, 2007, 130 (06) :1120-1133

[10]

A novel mechanism for activation of the protein kinase aurora A [J].

Eyers, PA ;

Erikson, E ;

Chen, LG ;

Maller, JL .

CURRENT BIOLOGY, 2003, 13 (08) :691-697

← 1 2 3 4 5 6 →