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Loss of cardioprotection with ageing

被引：285
作者：
Boengler, Kerstin [1 ]
Schulz, Rainer [1 ]
Heusch, Gerd [1 ]
机构：
[1] Univ Klinikum Essen, Inst Pathophysiol, D-45122 Essen, Germany
来源：
CARDIOVASCULAR RESEARCH | 2009年 / 83卷 / 02期
关键词：
Cardioprotection; Ischaemic preconditioning; Ischaemic postconditioning; Myocardial infarction; Myocardial ischaemia; Reperfusion; Ageing; PROTEIN-KINASE-C; ISCHEMIA-REPERFUSION INJURY; MITOCHONDRIAL PERMEABILITY TRANSITION; TERM CALORIC RESTRICTION; RAT-HEART MITOCHONDRIA; K-ATP CHANNELS; MYOCARDIAL ISCHEMIA/REPERFUSION INJURY; SPONTANEOUSLY HYPERTENSIVE-RATS; ELECTRON-TRANSPORT CHAIN; FREE-RADICAL GENERATION;
D O I：
10.1093/cvr/cvp033
中图分类号：
R5 [内科学];
学科分类号：
100201 [内科学];
摘要：
The present review discusses changes in protein expression and cell signalling important to ischaemia/reperfusion injury with myocardial ageing. The efficacy of cardioprotective manoeuvres, e.g. ischaemic pre and postconditioning in aged organs and animals will be discussed, and the development of strategies aimed to antagonize the age-induced loss of protection will be addressed.
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页码：247 / 261
页数：15
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