Localization of Th-cell subsets in inflammation: differential thresholds for extravasation of Th1 and Th2 cells

被引：75

作者：

D'Ambrosio, D ^{[1
]}

Iellem, A

Colantonio, L

Clissi, B

Pardi, R

Sinigaglia, F

机构：

[1] Roche Milano Ric, Milan, Italy

[2] Hosp San Raffaele, Dibit, Human Immunol Unit, I-20132 Milan, Italy

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 04期

关键词：

D O I：

10.1016/S0167-5699(00)01590-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The recruitment of T helper 1 (Th1) and Th2 cells into peripheral tissues is essential for inflammation and the host response to infections. Here, Daniele D'Ambrosio and colleagues review the traffic signals that enable the distinct positioning of Th1 and Th2 cells and argue that differential thresholds for extravasation constitute a critical aspect of their selective localization to inflamed tissues.

引用

页码：183 / 186

页数：4

共 38 条

[1] Functional diversity of helper T lymphocytes
Abbas, AK
Murphy, KM
Sher, A
[J]. NATURE, 1996, 383 (6603) : 787 - 793
[2] P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues
Austrup, F
Vestweber, D
Borges, E
Lohning, M
Brauer, R
Herz, U
Renz, H
Hallmann, R
Scheffold, A
Radbruch, A
Hamann, A
[J]. NATURE, 1997, 385 (6611) : 81 - 83
[3] Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
Bonecchi, R
Bianchi, G
Bordignon, PP
D'Ambrosio, D
Lang, R
Borsatti, A
Sozzani, S
Allavena, P
Gray, PA
Mantovani, A
Sinigaglia, F
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (01) : 129 - 134
[4] Lymphocyte homing and homeostasis
Butcher, EC
Picker, LJ
[J]. SCIENCE, 1996, 272 (5258) : 60 - 66
[5] CLISSI B, IN PRESS J IMMUNOL
[6] Induction of airway mucus production by T helper 2 (Th2) cells: A critical role for interleukin 4 in cell recruitment but not mucus production
Cohn, L
Homer, RJ
Marinov, A
Rankin, J
Bottomly, K
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (10) : 1737 - 1747
[7] Upregulation of integrin α6/β1 and chemokine receptor CCR1 by interleukin-12 promotes the migration of human type 1 helper T cells
Colantonio, L
Iellem, A
Clissi, B
Pardi, R
Rogge, L
Sinigaglia, F
D'Ambrosio, D
[J]. BLOOD, 1999, 94 (09) : 2981 - 2989
[8] D'Ambrosio D, 1998, J IMMUNOL, V161, P5111
[9] CD44 and its ligand hyaluronate mediate rolling under physiologic flow: A novel lymphocyte-endothelial cell primary adhesion pathway
DeGrendele, HC
Estess, P
Picker, LJ
Siegelman, MH
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (03) : 1119 - 1130
[10] Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells
Fuhlbrigge, RC
Kieffer, JD
Armerding, D
Kupper, TS
[J]. NATURE, 1997, 389 (6654) : 978 - 981

← 1 2 3 4 →