Non-viral causes of liver cancer: Does obesity led inflammation play a role?

被引：76

作者：

Alzahrani, Badr

Iseli, Tristan J.

Hebbard, Lionel W. ^{[1
]}

机构：

[1] Univ Sydney, Westmead Millennium Inst, Storr Liver Unit, Westmead, NSW 2145, Australia

来源：

CANCER LETTERS | 2014年 / 345卷 / 02期

基金：

英国医学研究理事会;

关键词：

Obesity; Liver cancer; Inflammation; NF-KAPPA-B; ADIPONECTIN KNOCKOUT MICE; HEPATIC STELLATE CELLS; TOLL-LIKE RECEPTORS; HEPATOCELLULAR-CARCINOMA; INSULIN-RESISTANCE; NONALCOHOLIC STEATOHEPATITIS; DIABETIC-PATIENTS; TUMOR-FORMATION; T-CADHERIN;

D O I：

10.1016/j.canlet.2013.08.036

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Liver cancer is the fifth most common cancer worldwide and the third most common cause of cancer mortality. Hepatocellular carcinoma (HCC) accounts for around 90% of primary liver cancers. Chronic infection with hepatitis B and hepatitis C viruses are two of most common causes of liver cancer. However, there are non-viral factors that are associated with liver cancer development. Numerous population studies have revealed strong links between obesity and the development of liver cancer. Obesity can alter hepatic pathology, metabolism and promote inflammation, leading to nonalcoholic fatty liver disease (NAFLD) and the progression to the more severe form, non-alcoholic steatohepatitis (NASH). NASH is characterised by prominent steatosis and inflammation, and can lead to HCC. Here, we discuss the role of obesity in inflammation and the principal signalling mechanisms involved in HCC formation. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：223 / 229

页数：7

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