CIMPle origin for promoter hypermethylation in colorectal cancer?

被引：21

作者：

Schuebel, Kornel ^{[1
]}

Chen, Wei ^{[1
]}

Baylin, Stephen B. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Div Canc Biol, Baltimore, MD 21218 USA

来源：

NATURE GENETICS | 2006年 / 38卷 / 07期

关键词：

D O I：

10.1038/ng0706-738

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The proposal that a distinct subset of colorectal cancers show a marked propensity for promoter CpG island DNA methylation and associated gene silencing has been hotly debated. A new study takes an unbiased approach and not only strongly concludes that a CpG island methylator phenotype exists, but also offers new markers to define a concept that could teach much about the origins of cancer.

引用

页码：738 / 740

页数：4

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