Cognitive function and brain structure correlations in healthy elderly East Asians

被引：94

作者：

Chee, Michael W. L. ^{[1
]}

Chen, Karren H. M. ^{[1
]}

Zheng, Hui ^{[1
]}

Chan, Karen P. L. ^{[1
]}

Isaac, Vivian ^{[1
]}

Sim, Sam K. Y. ^{[1
]}

Chuah, Lisa Y. M. ^{[1
]}

Schuchinsky, Maria ^{[1
]}

Fischl, Bruce ^{[2
]}

Ng, Tze Pin ^{[3
]}

机构：

[1] Duke NUS Grad Med Sch Singapore, Cognit Neurosci Lab, Singapore 169611, Singapore

[2] Harvard Univ, Sch Med, Athinoula A Martinos Ctr Biomed Imaging, Dept Radiol,Massachusetts Gen Hosp, Charlestown, MA USA

[3] Natl Univ Singapore, Fac Med, Gerontol Res Programme, Singapore 117548, Singapore

来源：

NEUROIMAGE | 2009年 / 46卷 / 01期

关键词：

Cognitive aging; Cohort studies; MRI; Volumetry; Cortical thickness; White matter; BODY-MASS INDEX; HUMAN CEREBRAL-CORTEX; ALZHEIMERS-DISEASE; INTRACRANIAL VOLUME; HIPPOCAMPAL VOLUME; CORTICAL VOLUME; OLDER-ADULTS; RISK-FACTORS; HEAD SIZE; FOLLOW-UP;

D O I：

10.1016/j.neuroimage.2009.01.036

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the effect of age and health variables known to modulate cognitive aging on several measures of cognitive performance and brain volume in a cohort of healthy, non-demented persons of Chinese descent aged between 55 and 86 years. 248 subjects contributed combined neuropsychological, MR imaging, health and socio-demographic information. Speed of processing showed the largest age-related decline. Education and plasma homocysteine levels modulated age-related decline in cognitive performance. Total cerebral volume declined at an annual rate of 0.4%/yr. Gray and white matter volume loss was comparable in magnitude. Regionally, there was relatively greater volume loss in the lateral prefrontal cortex bilaterally, around the primary visual cortex as well as bilateral superior parietal cortices. Speed of processing showed significant positive correlation with gray matter volume in several frontal, parietal and midline occipital regions bilaterally. In spite of differences in diet, lifestyle and culture, these findings are broadly comparable to studies conducted in Caucasian populations and suggest generalizability of processes involved in age-related decline in cognition and brain volume. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：257 / 269

页数：13

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