CDKs and cyclins in transition(s)

被引：66

作者：

Fisher, RP

机构：

[1] Program in Cell Biology and Genetics, Mem. Sloan-Kettering Cancer C., New York

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1997年 / 7卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(97)80106-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Understanding of cyclin-dependent kinase (CDK) regulation in mammalian cells has deepened even as the functions ascribed to these enzymes have multiplied. We know from crystallographic studies how a prototypic CDK-cyclin complex is activated and inactivated; the challenge now is to extend this knowledge to other CDKs involved in cell cycle progression. At the same time, as CDKs turn up in some unexpected places, interest in CDK regulation has spread beyond the cell cycle field.

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页码：32 / 38

页数：7

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