Apomorphine can sustain the long-duration response to L-DOPA in fluctuating PD

被引：46

作者：

Nutt, JG

Carter, JH

机构：

[1] Oregon Hlth Sci Univ, Sch Med, Dept Neurol, Portland, OR 97201 USA

[2] Oregon Hlth Sci Univ, Sch Med, Dept Physiol & Pharmacol, Portland, OR 97201 USA

[3] Oregon Hlth Sci Univ, Sch Nursing, Portland, OR 97201 USA

来源：

NEUROLOGY | 2000年 / 54卷 / 01期

关键词：

long-duration response; short-duration response; levodopa; apomorphine;

D O I：

10.1212/WNL.54.1.247

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors investigated the ability of daytime infusions of apomorphine, a D-1 and D-2 dopamine agonist, to sustain the long duration response (LDR) in seven subjects with fluctuating PD in whom L-DOPA was discontinued for 3 days. Apomorphine maintained the LDR to the extent that it kept the subjects "on" during the day. This observation suggests that the LDR can be a postsynaptic effect, independent of dopamine storage.

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页码：247 / 250

页数：4

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