Circadian rhythmicity by autocatalysis

被引：54

作者：

Mehra, Arun

Hong, Christian I.

Shi, Mi

Loros, Jennifer J.

Dunlap, Jay C.

Ruoff, Peter ^{[1
]}

机构：

[1] Univ Stavanger, Dept Math & Nat Sci, Stavanger, Norway

[2] Dartmouth Coll, Sch Med, Dept Genet, Hanover, NH 03755 USA

[3] Dartmouth Coll, Sch Med, Dept Biochem, Hanover, NH 03755 USA

来源：

PLOS COMPUTATIONAL BIOLOGY | 2006年 / 2卷 / 07期

关键词：

D O I：

10.1371/journal.pcbi.0020096

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The temperature compensated in vitro oscillation of cyanobacterial KaiC phosphorylation, the first example of a thermodynamically closed system showing circadian rhythmicity, only involves the three Kai proteins (KaiA, KaiB, and KaiC) and ATP. In this paper, we describe a model in which the KaiA- and KaiB-assisted autocatalytic phosphorylation and dephosphorylation of KaiC are the source for circadian rhythmicity. This model, based upon autocatalysis instead of transcription-translation negative feedback, shows temperature-compensated circadian limit-cycle oscillations with KaiC phosphorylation profiles and has period lengths and rate constant values that are consistent with experimental observations.

引用

页码：816 / 823

页数：8

共 39 条

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