A selective effect of Mp1 ligand on mRNA stabilization during megakaryocyte differentiation

被引:3
作者
Kaluzhny, Y
Hechler, B
Lu, J
Nguyen, HG
Cataldo, LM
Ravid, K
机构
[1] Boston Univ, Sch Med, Dept Biochem, Boston, MA 02118 USA
[2] Boston Univ, Sch Med, Ctr Canc, Boston, MA 02118 USA
[3] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Boston, MA 02118 USA
关键词
megakaryocyte; megakaryopoiesis; mRNA; message stability; Mp1; ligand;
D O I
10.1016/S0014-5793(02)03230-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Megakaryocytes, the platelet precursors, are induced to differentiate in response to Mpl ligand. Here we report that stability of the megakaryocyte-specific platelet factor 4 (PF4) mRNA is substantially augmented in the presence of Mpl ligand. This stabilization requires protein synthesis, but the 3'-untranslated region of PF4 mRNA is not sufficient for granting the effect. This cytokine also significantly or mildly stabilizes Mpl receptor or GAPDH mRNAs, respectively, in contrast to a previously reported lack of effect on P2Y(1) receptor mRNA. Our study is the first to suggest that Mpl ligand-induced lineage specification is also determined by message stabilization. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
引用
收藏
页码:279 / 283
页数:5
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