A novel tin-free procedure for alkyl radical reactions

被引：39

作者：

Benati, L ^{[1
]}

Leardini, R ^{[1
]}

Minozzi, M ^{[1
]}

Nanni, D ^{[1
]}

Scialpi, R ^{[1
]}

Spagnolo, P ^{[1
]}

Strazzari, S ^{[1
]}

Zanardi, G ^{[1
]}

机构：

[1] Univ Bologna, Dipartimento Chim Organ A Mangini, I-40136 Bologna, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 27期

关键词：

fragmentations; isocyanides; radical reactions; synthetic methods; thiols;

D O I：

10.1002/anie.200454245

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Desulfuration as a source of alkyl radicals: The addition of alkylsulfanyl radicals to isocyanides gives the corresponding alkyl radicals. This methodology can replace the usual tin-mediated radical procedures and allows for the generation of tertiary, secondary, and even nonstabilized primary radicals that can be used efficiently in reductive defunctionalizations and intermolecular additions to electron-rich olefins (see scheme).

引用

页码：3598 / 3601

页数：4

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