The contribution of dormant origins to genome stability: From cell biology to human genetics

被引：84

作者：

Alver, Robert C. ^{[1
]}

Chadha, Gaganmeet Singh ^{[1
]}

Blow, J. Julian ^{[1
]}

机构：

[1] Univ Dundee, Coll Life Sci, Ctr Gene Regulat & Express, Dundee DD1 5EH, Scotland

来源：

DNA REPAIR | 2014年 / 19卷

基金：

英国惠康基金;

关键词：

MCM2-7; Origin licensing; Replication origins; Dormant origins; Meier-Gorlin; Pre-RC; MINICHROMOSOME MAINTENANCE PROTEINS; REPLICATION FACTORY ACTIVATION; EUKARYOTIC DNA-REPLICATION; COMMON FRAGILE SITES; S-PHASE CHECKPOINT; RECOGNITION COMPLEX; MCM PROTEINS; CHROMOSOME SEGREGATION; WIDE IDENTIFICATION; EXCESS MCM2-7;

D O I：

10.1016/j.dnarep.2014.03.012

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The ability of a eukaryotic cell to precisely and accurately replicate its DNA is crucial to maintain genome stability. Here we describe our current understanding of the process by which origins are licensed for DNA replication and review recent work suggesting that fork stalling has exerted a strong selective pressure on the positioning of licensed origins. In light of this, we discuss the complex and disparate phenotypes observed in mouse models and humans patients that arise due to defects in replication licensing proteins. (C) 2014 The Authors. Published by Elsevier B.V.

引用

页码：182 / 189

页数：8

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