Hyaluronic Acid Conjugates as Vectors for the Active Targeting of Drugs, Genes and Nanocomposites in Cancer Treatment

被引：115

作者：

Arpicco, Silvia ^{[1
]}

Milla, Paola ^{[1
]}

Stella, Barbara ^{[1
]}

Dosio, Franco ^{[1
]}

机构：

[1] Univ Turin, Dept Drug Sci & Technol, Dipartimento Sci & Tecnol Farmaco, I-10125 Turin, Italy

来源：

MOLECULES | 2014年 / 19卷 / 03期

关键词：

bioconjugates; drug delivery; hyaluronic acid; anticancer agents; imaging agents; genes; SELF-ASSEMBLED NANOPARTICLES; MESOPOROUS SILICA NANOPARTICLES; IN-VIVO; BREAST-CANCER; INTRACELLULAR DELIVERY; ANTITUMOR-ACTIVITY; CARBON NANOTUBES; HYDROSOLUBLE BIOCONJUGATE; LOADED NANOPARTICLES; MOLECULAR-WEIGHT;

D O I：

10.3390/molecules19033193

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Hyaluronic acid (HA) is a naturally-occurring glycosaminoglycan and a major component of the extracellular matrix. Low levels of the hyaluronic acid receptor CD44 are found on the surface of epithelial, hematopoietic, and neuronal cells; it is overexpressed in many cancer cells, and in particular in tumor-initiating cells. HA has recently attracted considerable interest in the field of developing drug delivery systems, having been used, as such or encapsulated in different types of nanoassembly, as ligand to prepare nano-platforms for actively targeting drugs, genes, and diagnostic agents. This review describes recent progress made with the several chemical strategies adopted to synthesize conjugates and prepare novel delivery systems with improved behaviors.

引用

页码：3193 / 3230

页数：38

共 139 条

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Target Delivery and Cell Imaging Using Hyaluronic Acid-Functionalized Graphene Quantum Dots [J].