The antiviral effect of interferon-beta against SARS-coronavirus is not mediated by MxA protein

被引：51

作者：

Spiegel, M

Pichlmair, A

Mühlberger, E

Haller, O

Weber, F ^{[1
]}

机构：

[1] Univ Freiburg, Inst Med Mikrobiol & Hyg, Abt Virol, D-79008 Freiburg, Germany

[2] Univ Marburg, Inst Virol, D-35037 Marburg, Germany

来源：

JOURNAL OF CLINICAL VIROLOGY | 2004年 / 30卷 / 03期

关键词：

SARS-coronavirus; interferon; MxA protein; virus inhibition;

D O I：

10.1016/j.jcv.2003.11.013

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus termed SARS-CoV No antiviral treatment has been established so far. Interferons are cytokines which induce the synthesis of several antivirally active proteins in the cell. In this study, we demonstrated that multiplication of SARS-CoV in cell culture can be strongly inhibited by pretreatment with interferon-beta. Interferon-alpha and interferon-gamma, by contrast, were less effective. The human MxA protein is one of the most prominent proteins induced by interferon-beta. Nevertheless, no interference with SARS-CoV replication was observed in Vero cells stably expressing MxA. Therefore, other interferon-induced proteins must be responsible for the strong inhibitory effect of interferon-beta against SARS-CoV. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：211 / 213

页数：3

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