Age at onset of dementia and age of menopause in women with Down's syndrome

被引：48

作者：

Cosgrave, MP

Tyrrell, J

McCarron, M

Gill, M

Lawlor, BA

机构：

[1] Univ Dublin Trinity Coll, Dept Psychiat, Dublin 2, Ireland

[2] St Patricks & St James Hosp, Dept Old Age Psychiat, Dublin, Ireland

[3] Univ Dublin Trinity Coll, Dept Genet, Dublin 2, Ireland

来源：

JOURNAL OF INTELLECTUAL DISABILITY RESEARCH | 1999年 / 43卷

关键词：

Alzheimer's disease; correlation; dementia; Down's syndrome; menopause;

D O I：

10.1046/j.1365-2788.1999.00192.x

中图分类号：

G76 [特殊教育];

学科分类号：

040109 [特殊教育学];

摘要：

Menstrual status and the age of menopause were investigated in 143 Irish females with Down's syndrome (DS). The average age of menopause in 42 subjects (44.7 years) was younger than in the general population. The age at onset of dementia correlated with the age of menopause. This finding may be a manifestation of accelerated ageing in DS or point to oestrogen deficiency being an independent risk factor for the development of Alzheimer's dementia in DS. The implications of this finding for possible treatments are discussed.

引用

页码：461 / 465

页数：5

共 21 条

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