Antioxidant activity of L-adrenaline: A structure-activity insight

L-Adrenaline belongs to a group of the compounds known as catecholamines, which play an important role in the regulation of physiological process in living organisms. The antioxidant activity and antioxidant mechanism Of L-adrenaline was clarified using various in vitro antioxidant assays including 1,1-diphenyl-2-picryl-hydrazyl (DPPH center dot),2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), N,N-dimethyl-p-phenylenediamine (DMPD center dot+), and superoxide anion radicals (O-2(center dot-)) scavenging activity, hydrogen peroxide (H2O2), total antioxidant activity, ferric ions (Fe3+) and cupric ions (Cu2+) reducing ability, ferrous ions (Fe2+) chelating activity. L-Adrenaline inhibited 74.2% lipid peroxidation of a linoleic acid emulsion at 30 mu g/ml. concentration. On the other hand, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol and trolox displayed 83.3,82.1, 68.1 and 81.3% inhibition on the peroxidation of linoleic acid emulsion at the same concentration, respectively. BHA, BHT, a-tocopherol and trolox were used as reference antioxidants and radical scavenger compounds. Moreover, this study will bring an innovation for further studies related to antioxidant properties of L-adrenaline. According to present study, L-adrenaline had effective in vitro antioxidant and radical scavenging activity. (c) 2008 Elsevier Ireland Ltd. All rights reserved.