A novel dealkylation affording 3-aminoimidazo[1,2-a]pyridines:: access to new substitution patterns by solid-phase synthesis

被引：83

作者：

Blackburn, C ^{[1
]}

Guan, B ^{[1
]}

机构：

[1] Millennium Pharmaceut, Cambridge, MA 02139 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 10期

关键词：

D O I：

10.1016/S0040-4039(00)00003-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The three-component synthesis of 5-aminoimidazo[1,2-a]pyridine derivatives has been extended by a novel acid-induced dealkyation reaction that removes the 1,1,3,3-tetramethylbutyl group derived from the isonitrile input. This reaction was conducted on the solid-phase using the HMBA linker and the resulting products subjected to reductive alkylation using several aldehydes, thereby accessing novel substitution patterns at the 3-position. (C) 2000 Elsevier Science Ltd.. All rights reserved.

引用

页码：1495 / 1500

页数：6

共 30 条

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