Phenolics from commercialized grape extracts prevent early atherosclerotic lesions in hamsters by mechanisms other than antioxidant effect

被引:91
作者
Auger, C
Gérain, P
Laurent-Bichon, F
Portet, K
Bornet, A
Caporiccio, B
Cros, G
Teissédre, PL
Rouanet, JM [1 ]
机构
[1] Univ Montpellier 2, Equipe Accueil 3762, Dept Agroressources & Proc Biol, Pl Eugene Bataillon, F-34095 Montpellier 05, France
[2] Univ Montpellier, Fac Pharm, Lab Pharmacol & Physiopathol Expt, F-34093 Montpellier 05, France
[3] Univ Montpellier I, Fac Pharm, UMR 1083, F-34093 Montpellier 5, France
关键词
phenolic extracts; atherosclerosis; hamster; rat aortic rings; vasorelaxation;
D O I
10.1021/jf040125d
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
The aim of this study was to evaluate the antiatherosclerotic effect of commercially available phenolic-rich extracts from grape seeds (ExGrape seeds, EGS; grape seed extract, GSE) and marc (ExGrape total, EGT) in cholesterol-fed hamsters and to investigate possible operating mechanisms. These extracts fed at a moderate dose mimicking two glasses of red wine per meal reduced plasma cholesterol (-11% on average) but did not affect plasma antioxidant capacity of hamsters. The extracts prevented the development of aortic atherosclerosis by 68% (EGS), 63% (EGT), and 34% (GSE). Elsewhere, in an ex vivo experiment using rat aortic rings, EGS (7 mug/mL) induced 77% endothelium-dependent relaxation, whereas EGT and GSE (30 mug/mL) induced 84 and 72%, respectively. These results suggests that phenolic extracts from grape seeds and marc are beneficial in inhibiting atherosclerosis by indirect mechanism(s).
引用
收藏
页码:5297 / 5302
页数:6
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