Autosomal dominant polycystic kidney disease: A two-hit model

被引：25

作者：

Germino, GG

机构：

[1] Johns Hopkins School of Medicine, Baltimore, MD

来源：

HOSPITAL PRACTICE | 1997年 / 32卷 / 03期

关键词：

D O I：

10.1080/21548331.1997.11443444

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The clinical and histopathologic variability of this common genetic disorder-a leading cause of renal failure-cannot be explained by inherited mutation. Instead, the disease evidently progresses by a second hit: somatic mutation superimposed on germline mutation. The source of the mutability appears to be DNA triple-helixing, as mediated by some odd genetic code, the longest polypyrimidine tract ever found in the human genome.

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页码：81 / +

页数：1

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