Brief informant screening test for mild cognitive impairment and early Alzheimer's disease

被引:43
作者
Li, Minglei [1 ]
Ng, Tze Pin [1 ]
Kua, Ee Heok [1 ]
Ko, Soo Meng [1 ]
机构
[1] Natl Univ Singapore, Dept Psychol Med, Gerontol Res Programme, Singapore 117548, Singapore
关键词
mild cognitive impairment; Alzheimer's disease; screening test for mild cognitive impairment; neuropsychological tests; instrumental activities of daily living;
D O I
10.1159/000092808
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background/Aims: Recent research has attempted combinations of instruments to improve screening accuracy for mild cognitive impairment (MCI) and early Alzheimer's disease (AD). We compared Mini-Mental State Examination (MMSE), Immediate and Delayed Recall ( Logical Memory I and II; LM-I and LM-II, respectively), a single-item informant report of memory problem (IRMP), and a four-item Instrumental Activities of Daily Living (4IADL) scale, and combinations of these tests. Method: The tests were administered together with Clinical Dementia Rating (CDR) to subjects who were cognitively intact ( CDR = 0, n = 88), and with diagnoses of MCI ( CDR = 0.5, n = 37) and early AD ( CDR = 1 - 2, n = 19). Results: Screening accuracy ( receiver operating characteristic area under curve, AUC) for identifying MCI or MCI-AD was lowest for MMSE ( AUC 67.6% for MCI or 77.9% for MCI-AD), and better for IRMP (79.5 or 83.2%), 4IADL (76.9 or 84.7%), LM-I ( 81.2 or 87.1%) and LM-II (86.1 or 90.8%). Combining IRMP, 4IADL and LM-II was most accurate ( AUC 91.7% for MCI or 94.5% for MCI-AD); sensitivity: 86.5 or 89.3%; specificity: 86.4 or 88.6%. However, combining IRMP and 4IADL gave nearly as good accuracy (AUC 87.2 or 91.6%); sensitivity: 86.5 or 85.7%; specificity: 79.5 or 85.2%. Conclusion: A brief instrument combining an IRMP and 4IADL items is potentially useful in screening for MCI and early AD. Copyright (C) 2006 S. Karger AG, Basel.
引用
收藏
页码:392 / 402
页数:11
相关论文
共 39 条
[1]   Disability and mild cognitive impairment: A longitudinal population-based study [J].
Artero, S ;
Touchon, J ;
Ritchie, K .
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2001, 16 (11) :1092-1097
[2]   INSTRUMENTAL ACTIVITIES OF DAILY LIVING AS A SCREENING TOOL FOR COGNITIVE IMPAIRMENT AND DEMENTIA IN ELDERLY COMMUNITY DWELLERS [J].
BARBERGERGATEAU, P ;
COMMENGES, D ;
GAGNON, M ;
LETENNEUR, L ;
SAUVEL, C ;
DARTIGUES, JF .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1992, 40 (11) :1129-1134
[3]   Screening for cognitive impairment in general practice: Toward a consensus [J].
Brodaty, H ;
Clarke, J ;
Ganguli, M ;
Grek, A ;
Jorm, AF ;
Khachaturian, Z ;
Scherr, P .
ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 1998, 12 (01) :1-13
[4]   Prose recall in dementia - A comparison of delay intervals [J].
Chapman, LL ;
White, DA ;
Storandt, M .
ARCHIVES OF NEUROLOGY, 1997, 54 (12) :1501-1504
[5]   The performance of instrumental-activities of daily living scale in screening for cognitive impairment in elderly community residents [J].
Cromwell, DA ;
Eagar, K ;
Poulos, RG .
JOURNAL OF CLINICAL EPIDEMIOLOGY, 2003, 56 (02) :131-137
[6]   MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].
FOLSTEIN, MF ;
FOLSTEIN, SE ;
MCHUGH, PR .
JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198
[7]   CLINICAL STAGING OF DEMENTIA IN A POPULATION SURVEY - COMPARISON OF DSM-III-R AND THE WASHINGTON-UNIVERSITY CLINICAL DEMENTIA RATING-SCALE [J].
FORSELL, Y ;
FRATIGLIONI, L ;
GRUT, M ;
VIITANEN, M ;
WINBLAD, B .
ACTA PSYCHIATRICA SCANDINAVICA, 1992, 86 (01) :49-54
[8]  
Galasko D, 1997, ALZ DIS ASSOC DIS, V11, pS33
[9]   CEREBRAL BLOOD-FLOW IN DEMENTIA [J].
HACHINSKI, VC ;
ILIFF, LD ;
ZILHKA, E ;
DUBOULAY, GH ;
MCALLISTER, VL ;
MARSHALL, J ;
RUSSELL, RWR ;
SYMON, L .
ARCHIVES OF NEUROLOGY, 1975, 32 (09) :632-637
[10]   A RATING SCALE FOR DEPRESSION [J].
HAMILTON, M .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1960, 23 (01) :56-62