Cerebrospinal fluid cytokines in Salmonella urbana encephalopathy

被引：12

作者：

Minami, K ^{[1
]}

Yanagawa, T ^{[1
]}

Okuda, M ^{[1
]}

Suzuki, H ^{[1
]}

Tamura, A ^{[1
]}

Izumi, G ^{[1
]}

Yoshikawa, N ^{[1
]}

机构：

[1] Wakayama Med Univ, Sch Med, Dept Pediat, Wakayama 6410012, Japan

来源：

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 2004年 / 203卷 / 02期

关键词：

Salmonella urbana; encephalopathy; cytokines;

D O I：

10.1620/tjem.203.129

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

We present a case report of encephalopathy associated with Salmonella urbana infection in a child. A 5-year-old boy was admitted to our clinic with convulsions and coma. Cerebrospinal fluid (CSF) interleukin-6 (IL-6) and IL-8 were elevated at onset and were decreased within normal limit on the fifth day. Residual neurological deficits included severe mental deficits and spastic tetraplegia. High levels of CSF proinflammatory cytokines might be related to central nervous system (CNS) disease activity. Although encephalopathy is a rare complication of non-typhi Salmonella infection, it should be borne in mind as an occasionally serious and potentially lethal disease.

引用

页码：129 / 132

页数：4

共 13 条

[1]

Clinical and pathologic characteristics of nontyphoidal salmonella encephalopathy [J].

Arii, J ;

Tanabe, Y ;

Miyake, M ;

Mukai, T ;

Matsuzaki, M ;

Niinomi, N ;

Watanabe, H ;

Yokota, Y ;

Kohno, Y ;

Noda, M .

NEUROLOGY, 2002, 58 (11) :1641-1645

[2]

NEUROLOGIC DISEASE INDUCED IN TRANSGENIC MICE BY CEREBRAL OVEREXPRESSION OF INTERLEUKIN-6 [J].

CAMPBELL, IL ;

ABRAHAM, CR ;

MASLIAH, E ;

KEMPER, P ;

INGLIS, JD ;

OLDSTONE, MBA ;

MUCKE, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (21) :10061-10065

[3]

Gomez HF, 1998, TXB PEDIAT INFECT DI, P1321

[4]

Tumor necrosis factor-α, interleukin-1β, and interleukin-6 in cerebrospinal fluid from children with prolonged febrile seizures -: Comparison with acute encephalitis/encephalopathy [J].

Ichiyama, T ;

Nishikawa, M ;

Yoshitomi, T ;

Hayashi, T ;

Furukawa, S .

NEUROLOGY, 1998, 50 (02) :407-411

[5]

Host responses to pathogenic Salmonella infection [J].

Jones, BD .

GENES & DEVELOPMENT, 1997, 11 (06) :679-687

[6]

ENCEPHALOPATHY ASSOCIATED WITH SALMONELLA-ENTERITIDIS INFECTION [J].

MARTIN, K ;

SHARLAND, M ;

DAVIES, EG .

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 1994, 26 (04) :486-488

[7]

Immunobiology of the blood-brain barrier [J].

Miller, DW .

JOURNAL OF NEUROVIROLOGY, 1999, 5 (06) :570-578

[8]

Induction of pro-inflammatory cytokine mRNAs in the brain after peripheral injection of subseptic doses of lipopolysaccharide in the rat [J].

Quan, N ;

Stern, EL ;

Whiteside, MB ;

Herkenham, M .

JOURNAL OF NEUROIMMUNOLOGY, 1999, 93 (1-2) :72-80

[9]

Brain endothelial cell production of a neuroprotective cytokine, interleukin-6, in response to noxious stimuli [J].

Reyes, TM ;

Fabry, Z ;

Coe, CL .

BRAIN RESEARCH, 1999, 851 (1-2) :215-220

[10]

Salmonella infection acquired from reptilian pets [J].

Sanyal, D ;

Douglas, T ;

Roberts, R .

ARCHIVES OF DISEASE IN CHILDHOOD, 1997, 77 (04) :345-346

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