Phytotherapy in heart failure

被引：8

作者：

Loew, D

机构：

[1] Inst. F. Klinische Pharmakologie, Universität Frankfurt/Main

[2] Abt. F. Klinische Pharmakologie, Universität Frankfurt, 60596 Frankfurt/Main

来源：

PHYTOMEDICINE | 1997年 / 4卷 / 03期

关键词：

Crataegus extract; phytotherapy; pharmacology; randomized double-blind studies; NYHA grade II;

D O I：

10.1016/S0944-7113(97)80080-3

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

According to the results of experimental investigations, standardized Crataegus extracts differ markedly from other inotropic drugs used for the treatment of heart failure. Crataegus has positive inotropic, positive chronotropic, positive dromotropic but negative bathmotropic effects, increases coronary and myocardial perfusion, lowers peripheral resistance and has antiarrhythmic and economising action with respect to oxygen and energy consumption. In randomised double-blind clinical trials, key surrogates required for demonstration of efficacy in heart failure were improved. Defined Crataegus extracts accordingly represent an alternative to synthetic drugs in patients with NYHA Grade II heart failure.

引用

页码：267 / 271

页数：5