Effect of anticonvulsant drugs on interleukins-1,-2 and-6 and monocyte chemoattractant protein-1

被引：48

作者：

Verrotti, A

Basciani, F

Trotta, D

Greco, R

Morgese, G

Chiarelli, F

机构：

[1] Univ Chieti, Dept Med, Sect Pediat, Osped Policlin, I-66100 Chieti, Italy

[2] Univ Siena, Dept Pediat, I-53100 Siena, Italy

来源：

CLINICAL AND EXPERIMENTAL MEDICINE | 2001年 / 1卷 / 03期

关键词：

interleukins; chemokine; valproate; carbamazepine; epilepsy;

D O I：

10.1007/s10238-001-8024-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In order to evaluate whether treatment with valproic acid or carbamazepine can modify interleukins and monocyte chemoattractant protein-1, we studied 40 epileptic children and adolescents. We evaluated the patients before and after 1 year of therapy. At the end of follow-up, the patients showed a significant increase of the production of interleukin-1alpha, interleukin-1beta, interleukin-6, and monocyte chemoattractant protein-1; interleukin-2 production was significantly higher only in patients receiving carbamazepine. In conclusion, antiepileptic drugs can influence the immune system by modifying interleukin and chemokine concentrations; these changes seem to be independent of the serum concentrations of these drugs.

引用

页码：133 / 136

页数：4

共 19 条

[1] CYTOKINES IN NEURONAL CELL-TYPES [J].

BARTFAI, T ;

SCHULTZBERG, M .

NEUROCHEMISTRY INTERNATIONAL, 1993, 22 (05) :435-444

[2]

BENVENISTE EN, 1992, AM J PHYSIOL, V263, P1

[3] Does antiepileptic therapy affect immune response? [J].

De Sarro, GB ;

Berlinghieri, MC ;

Elia, M ;

Musumeci, SA ;

David, E ;

Dominijanni, A ;

Gulletta, E .

JOURNAL OF CHEMOTHERAPY, 1998, 10 (02) :184-186

[4] Kainic acid induced expression of interleukin-1 receptor antagonist mRNA in the rat brain [J].

Eriksson, C ;

Winblad, B ;

Schultzberg, M .

MOLECULAR BRAIN RESEARCH, 1998, 58 (1-2) :195-208

[5] INTERLEUKIN-6 AND THE ACUTE PHASE RESPONSE [J].

HEINRICH, PC ;

CASTELL, JV ;

ANDUS, T .

BIOCHEMICAL JOURNAL, 1990, 265 (03) :621-636

[6]

HOPKINS SJ, 1995, TRENDS NEUROSCI, V18, P83

[7] Sodium valproate inhibits production of TNF-α and IL-6 and activation of NF-κB [J].

Ichiyama, T ;

Okada, K ;

Lipton, JM ;

Matsubara, T ;

Hayashi, T ;

Furukawa, S .

BRAIN RESEARCH, 2000, 857 (1-2) :246-251

[8]

MINAMI M, 1990, BIOCHEM BIOPH RES CO, V171, P823

[9]

Nishimura H, 1997, CELL STRESS CHAPERON, V2, P50, DOI 10.1379/1466-1268(1997)002<0050:HPMIWS>2.3.CO

[10]

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