Influence of in vitro susceptibility phenotype against thrombin-induced platelet microbicidal protein on treatment and prophylaxis outcomes of experimental Staphylococcus aureus endocarditis

被引:21
作者
Dhawan, VK
Yeaman, MR
Bayer, AS
机构
[1] Univ Calif Los Angeles, Harbor Med Ctr, Div Infect Dis, St Johns Cardiovasc Res Ctr, Torrance, CA 90509 USA
[2] Univ Calif Los Angeles, Harbor Med Ctr, Div Adult Infect Dis, Torrance, CA 90509 USA
[3] Univ Calif Los Angeles, Sch Med, Los Angeles, CA USA
[4] Charles R Drew Univ Med & Sci, Martin Luther King Med Ctr, Div Infect Dis, Torrance, CA USA
关键词
D O I
10.1086/315063
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Thrombin-induced platelet microbicidal protein-1 (tPMP-1) is a small, cationic staphylocidal peptide from rabbit platelets. In the current study, the outcomes of vancomycin treatment and prophylaxis were compared in experimental infective endocarditis (IE) caused by an isogenic Staphylococcus aureus strain pair differing in tPMP-1 susceptibility (tPMP(S)) or resistance (tPMP(R)) in vitro (ISP479C and ISP479R, respectively). Vancomycin therapy (selected for its intrinsically slow bactericidal activity) reduced ISP479C (but not ISP479R) densities in vegetations compared with controls (P <.01), In contrast, prophylactic administration of vancomycin yielded no differences in efficacies for the 2 challenge strains. These data suggest that the tPMPR phenotype in vitro has a negative effect on the antimicrobial therapy (but not the prophylaxis) of experimental S. aureus IE. These disparate results may be explained in part by the requirement for microbicidal effects in the treatment of established IE, whereas prophylactic efficacy depends more on growth inhibitory and antiadhesion effects.
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页码:1561 / 1568
页数:8
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