Tat-SF1: Cofactor for stimulation of transcriptional elongation by HIV-1 Tat

被引：143

作者：

Zhou, QA

Sharp, PA

机构：

[1] MIT, CTR CANC RES, CAMBRIDGE, MA 02139 USA

[2] MIT, DEPT BIOL, CAMBRIDGE, MA 02139 USA

来源：

SCIENCE | 1996年 / 274卷 / 5287期

关键词：

D O I：

10.1126/science.274.5287.605

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tat may stimulate transcriptional elongation by recruitment of a complex containing Tat-SF1 and a kinase to the human immunodeficiency virus-type 1 (HIV-1) promoter through a Tat-TAR interaction. A complementary DNA for the cellular activity, Tat-SF1, has been isolated. This factor is required for Tat trans-activation and is a substrate of an associated cellular kinase, Cotransfection with the complementary DNA for Tat-SF1 specifically modulates Tat activation. Tat-SF1 contains two RNA recognition motifs and a highly acidic carboxyl-terminal half. It is distantly related to EWS and FUS/TLS, members of a family of putative transcription factors with RNA recognition motifs that are associated with sarcomas.

引用

页码：605 / 610

页数：6

共 46 条

[1]

ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999

[2] ELONGIN (SIII) - A MULTISUBUNIT REGULATOR OF ELONGATION BY RNA-POLYMERASE-II [J].