Is there really a power shortage in clinical trials testing the "homocysteine hypothesis?" Results from a substudy of the VITAmins TO Prevent Stroke (VITATOPS) Trial

被引：10

作者：

Hankey, GJ ^{[1
]}

Eikelboom, JW

Loh, K

Yi, Q

Pizzi, J

Tang, M

Hickling, S

Le, M

Klijn, CJM

Dusitanond, P

van Bockxmeer, F

Gelavis, A

Baker, R

Jamrozik, K

机构：

[1] Royal Perth Hosp, Stroke Unit, Perth, WA, Australia

[2] Royal Perth Hosp, Dept Haematol, Perth, WA, Australia

[3] Royal Perth Hosp, Dept Pathol, Perth, WA, Australia

[4] Royal Perth Hosp, Dept Pharm, Perth, WA, Australia

[5] Univ Western Australia, Sch Med & Pharmacol, Nedlands, WA 6009, Australia

[6] Univ Western Australia, Sch Populat Hlth, Nedlands, WA 6009, Australia

[7] Princess Margaret Hosp, Dept Biostat, Toronto, ON M4X 1K9, Canada

[8] Univ London Imperial Coll Sci Technol & Med, London, England

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2004年 / 24卷 / 08期

关键词：

D O I：

10.1161/01.ATV.0000136385.50973.68

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：E147 / E148

页数：2

共 9 条

[1]

Baker RI, 2002, CEREBROVASC DIS, V13, P120

[2] Power shortage: Clinical trials testing the "homocysteine hypothesis" against a background of folic acid-fortified cereal grain flour [J].

Bostom, AG ;

Selhub, J ;

Jacques, PF ;

Rosenberg, IH .

ANNALS OF INTERNAL MEDICINE, 2001, 135 (02) :133-139

[3]

Brattström L, 1998, BMJ-BRIT MED J, V316, P894, DOI 10.1136/bmj.316.7135.894

[4] Homocysteine and risk of ischemic heart disease and stroke -: A meta-analysis [J].

Clarke, R ;

Collins, R ;

Lewington, S ;

Donald, A ;

Alfthan, G ;

Tuomilehto, J ;

Arnesen, E ;

Bonaa, K ;

Blacher, J ;

Boers, GHJ ;

Bostom, A ;

Bots, ML ;

Grobee, DE ;

Brattström, L ;

Breteler, MMB ;

Hofman, A ;

Chambers, JC ;

Kooner, JS ;

Coull, BM ;

Evans, RW ;

Kuller, LH ;

Evers, S ;

Folsom, AR ;

Freyburger, G ;

Parrot, F ;

Genst, J ;

Dalery, K ;

Graham, IM ;

Daly, L ;

Hoogeveen, EK ;

Kostense, PJ ;

Stehouwer, CDA ;

Hopknis, PN ;

Jacques, P ;

Selhub, J ;

Luft, FC ;

Jungers, P ;

Lindgren, A ;

Lolin, YI ;

Loehrer, F ;

Fowler, B ;

Mansoor, MA ;

Malinow, MR ;

Ducimetiere, P ;

Nygard, O ;

Refsum, H ;

Vollset, SE ;

Ueland, PM ;

Omenn, GS ;

Beresford, SAA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (16) :2015-2022

[5] Homocyst(e)ine and cardiovascular disease: A critical review of the epidemiologic evidence [J].

Eikelboom, JW ;

Lonn, E ;

Genest, J ;

Hankey, G ;

Yusuf, S .

ANNALS OF INTERNAL MEDICINE, 1999, 131 (05) :363-375

[6] Homocysteine and vascular disease [J].

Hankey, GJ ;

Eikelboom, JW .

LANCET, 1999, 354 (9176) :407-413

[7]

SATCHELL FB, 1996, FED REGISTER, V61, P8781

[8] Vitamin intervention for stroke prevention (VISP) trial: Rationale and design [J].

Spence, JD ;

Howard, VJ ;

Chambless, LE ;

Malinow, MR ;

Pettigrew, LC ;

Stampfer, M ;

Toole, JF .

NEUROEPIDEMIOLOGY, 2001, 20 (01) :16-25

[9] Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death - The Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial [J].

Toole, JF ;

Malinow, MR ;

Chambless, LE ;

Spence, JD ;

Pettigrew, LC ;

Howard, VJ ;

Sides, EG ;

Wang, CH ;

Stampfer, M .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 291 (05) :565-575

← 1 →