PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways

被引：342

作者：

Abraham, RT ^{[1
]}

机构：

[1] Burnham Inst, Program Signal Transduct Res, La Jolla, CA 92130 USA

来源：

DNA REPAIR | 2004年 / 3卷 / 8-9期

关键词：

kinases; signaling pathway; ATM; mTOR;

D O I：

10.1016/j.dnarep.2004.04.002

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The phosphomositide 3-kinase related kinases (PIKKs) comprise a family of high molecular mass signaling proteins that play central roles in the control of cell growth, gene expression, and genome surveillance and repair in eukaryotic cells. Mammalian cells express six PIKK family members. five of which-ATM, ATR, mTOR, DNA-PK, and hSMG-1-function as protein serine-threosine kinases. This overview provides some general insights into the pharmacology, biochemistry, and function of this nonconventional group of protein kinases. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：883 / 887

页数：5

共 33 条

[1] Immunopharmacology of rapamycin
Abraham, RT
Wiederrecht, GJ
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 : 483 - 510
[2] Identification of TOR signaling complexes: more TORC for the cell growth engine
Abraham, RT
[J]. CELL, 2002, 111 (01) : 9 - 12
[3] FAT: a novel domain in PIK-related kinases
Bosotti, R
Isacchi, A
Sonnhammer, ELL
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (05) : 225 - 227
[4] A MAMMALIAN PROTEIN TARGETED BY G1-ARRESTING RAPAMYCIN-RECEPTOR COMPLEX
BROWN, EJ
ALBERS, MW
SHIN, TB
ICHIKAWA, K
KEITH, CT
LANE, WS
SCHREIBER, SL
[J]. NATURE, 1994, 369 (6483) : 756 - 758
[5] ATR and ATRIP: Partners in checkpoint signaling
Cortez, D
Guntuku, S
Qin, J
Elledge, SJ
[J]. SCIENCE, 2001, 294 (5547) : 1713 - 1716
[6] Requirement of ATM-dependent phosphorylation of BRCA1 in the DNA damage response to double-strand breaks
Cortez, D
Wang, Y
Qin, J
Elledge, SJ
[J]. SCIENCE, 1999, 286 (5442) : 1162 - 1166
[7] Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases
Cortez, D
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (39) : 37139 - 37145
[8] Edinger AL, 2003, CANCER RES, V63, P8451
[9] Regulation of translation initiation by FRAP/mTOR
Gingras, AC
Raught, B
Sonenberg, N
[J]. GENES & DEVELOPMENT, 2001, 15 (07) : 807 - 826
[10] Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
Hara, K
Maruki, Y
Long, XM
Yoshino, K
Oshiro, N
Hidayat, S
Tokunaga, C
Avruch, J
Yonezawa, K
[J]. CELL, 2002, 110 (02) : 177 - 189

← 1 2 3 4 →