Consequences of growth hormone (GH) overexpression and GH resistance

被引：91

作者：

Bartke, A ^{[1
]}

Chandrashekar, V

Bailey, B

Zaczek, D

Turyn, D

机构：

[1] So Illinois Univ, Sch Med, Dept Physiol, Carbondale, IL 62901 USA

[2] Univ Buenos Aires, CONICET, Fac Farm & Bioquim, Inst Quim & Fisicoquim Biol, RA-1113 Buenos Aires, DF, Argentina

来源：

NEUROPEPTIDES | 2002年 / 36卷 / 2-3期

关键词：

D O I：

10.1054/npep.2002.0889

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Development of transgenic mice overexpressing GH and GHR-KO mice with GH resistance provided novel animal models for study of the somatotropic axis and for identifying GH actions that may be relevant to its current and contemplated use in medicine and agriculture. Studies of phenotypic characteristics of these animals revealed previously unsuspected actions of GH and IGF-I on neuroendocrine functions related to reproduction and to the release of "stress hormones" (glucocorticoids and prolactin). These studies also provided novel and still-disputed evidence for involvement of somatotropic axis in the control of aging and life span and in mediating the actions of longevity genes. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：201 / 208

页数：8

共 81 条

[1]

The mouse intraovarian insulin-like growth factor I system: Departures from the rat paradigm [J].

Adashi, EY ;

Resnick, CE ;

Payne, DW ;

Rosenfeld, RG ;

Matsumoto, T ;

Hunter, MK ;

Gargosky, SE ;

Zhou, J ;

Bondy, CA .

ENDOCRINOLOGY, 1997, 138 (09) :3881-3890

[2]

Growth hormone and aging [J].

Bartke A. ;

Brown-Borg H. ;

Kinney B. ;

Mattison J. ;

Wright C. ;

Hauck S. ;

Coschigano K. ;

Kopchick J. .

Journal of the American Aging Association, 2000, 23 (4) :219-225

[3]

BARTKE A, 1994, P SOC EXP BIOL MED, V206, P345, DOI 10.3181/00379727-206-43771

[4]

Does growth hormone prevent or accelerate aging? [J].

Bartke, A ;

Brown-Borg, HM ;

Bode, AM ;

Carlson, J ;

Hunter, WS ;

Bronson, RT .

EXPERIMENTAL GERONTOLOGY, 1998, 33 (7-8) :675-687

[5]

Bartke A, 2000, J ANDROL, V21, P181

[6]

BARTKE A, 2001, TRENDS ENDOCRINOLOGY, V12

[7]

Baynes J.W., 1989, MAILLARD REACTION AG

[8]

Enhanced spontaneous locomotor activity in bovine GH transgenic mice involves peripheral mechanisms [J].

Bohlooly-Y, M ;

Ola, B ;

Gritli-Linde, A ;

Brusehed, O ;

Isaksson, OGP ;

Ohlsson, C ;

Söderpalm, B ;

Törnell, J .

ENDOCRINOLOGY, 2001, 142 (10) :4560-4567

[9]

Vascular function and blood pressure in GH transgenic mice [J].

Bohlooly-Y, M ;

Carlson, L ;

Olsson, B ;

Gustafsson, H ;

Andersson, IJL ;

Törnell, J ;

Bergström, G .

ENDOCRINOLOGY, 2001, 142 (08) :3317-3323

[10]

Impairment of cardiac function and bioenergetics in adult transgenic mice overexpressing the bovine growth hormone gene [J].

Bollano, E ;

Omerovic, E ;

Bohlooly-Y, M ;

Kujacic, V ;

Madhu, B ;

Törnell, J ;

Isaksson, O ;

Soussi, B ;

Schulze, W ;

Fu, MLX ;

Matejka, G ;

Waagstein, F ;

Isgaard, J .

ENDOCRINOLOGY, 2000, 141 (06) :2229-2235

← 1 2 3 4 5 6 7 8 9 →