Intestinal epithelial cells: regulators of barrier function and immune homeostasis

被引：2810

作者：

Peterson, Lance W. ^{[1
,2
]}

Artis, David ^{[1
,2
,3
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Inst Immunol, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2014年 / 14卷 / 03期

基金：

美国国家卫生研究院;

关键词：

INNATE LYMPHOID-CELLS; CD103(+) DENDRITIC CELLS; NF-KAPPA-B; POLYMERIC IMMUNOGLOBULIN RECEPTOR; DELTA INTRAEPITHELIAL LYMPHOCYTES; COMMON VARIABLE IMMUNODEFICIENCY; THYMIC STROMAL LYMPHOPOIETIN; GENOME-WIDE ASSOCIATION; CD8(+) T-CELLS; COMMENSAL-BACTERIA;

D O I：

10.1038/nri3608

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The abundance of innate and adaptive immune cells that reside together with trillions of beneficial commensal microorganisms in the mammalian gastrointestinal tract requires barrier and regulatory mechanisms that conserve host-microbial interactions and tissue homeostasis. This homeostasis depends on the diverse functions of intestinal epithelial cells (IECs), which include the physical segregation of commensal bacteria and the integration of microbial signals. Hence, IECs are crucial mediators of intestinal homeostasis that enable the establishment of an immunological environment permissive to colonization by commensal bacteria. In this Review, we provide a comprehensive overview of how IECs maintain host-commensal microbial relationships and immune cell homeostasis in the intestine.

引用

页码：141 / 153

页数：13

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