Immunological changes among farmers exposed to phenoxy herbicides: Preliminary observations

被引:61
作者
Faustini, A
Settimi, L
Pacifici, R
Fano, V
Zuccaro, P
Forastiere, F
机构
[1] IST SUPER SANITA,LAB IGIENE AMBIENTALE,I-00161 ROME,ITALY
[2] LOCAL HLTH UNIT,TARQUINIA,VT,ITALY
[3] DEPT ENVIRONM & OCCUPAT MED,LINKOPING,SWEDEN
[4] LAZIO REG HLTH AUTHOR,EPIDEMIOL UNIT,ROME,ITALY
关键词
immunological changes; farmers; phenoxy herbicides;
D O I
10.1136/oem.53.9.583
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Objectives-To evaluate short term immunological changes after agricultural exposure to commercial formulations of chlorophenoxy herbicides. Methods-Blood samples were collected hom 10 farmers within seven days before exposure, one to 12 days after exposure, and again 50 to 70 days after exposure. Whole blood was used to count lymphocyte subsets with monoclonal antibodies. Peripheral blood mononuclear (PBM) cells were used to measure natural killer (NK) cell activity and lymphocyte response to mitogenic stimulations. Values before exposure were used as reference. Results-in comparison with concentrations before exposure, a significant reduction was found one to 12 days after exposure in the following variables (P <0.05): circulating helper (CD4) and suppressor T cells (CD8), CD8 dim, cytotoxic T lymphocytes (CTL), natural killer cells (NK), and CD8 cells expressing the surface antigens HLA-DR (CD8-DR), and lymphoproliferative response to mitogen stimulations. All immunological values found 50-70 days after exposure were comparable with concentrations before exposure, but mitogenic proliferative responses of lymphocytes were still significantly decreased. Conclusions-According to our data agricultural exposure to commercial 2,4-dichlorophenoxyacetic acid (2,4-D) and 4-chloro-2-methylphenoxyacetic acid (MCPA) formulations may exert short term immunosuppressive effects. Further studies should clarify whether the immunological changes found may have health implications and can specifically contribute to cancer aetiology.
引用
收藏
页码:583 / 585
页数:3
相关论文
共 22 条
[1]  
ADAMS SL, 1991, VET HUM TOXICOL, V33, P209
[2]   CLUES TO CANCER ETIOLOGY FROM STUDIES OF FARMERS [J].
BLAIR, A ;
ZAHM, SH ;
PEARCE, NE ;
HEINEMAN, EF ;
FRAUMENI, JF .
SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH, 1992, 18 (04) :209-215
[3]   THE EFFECT OF ORAL-EXPOSURE TO THE N-BUTYLESTER OF 2,4-DICHLOROPHENOXYACETIC ACID ON THE IMMUNE-RESPONSE IN MICE [J].
BLAKLEY, BR .
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 1986, 8 (01) :93-99
[4]   THE EFFECT OF PRENATAL EXPOSURE TO THE N-BUTYLESTER OF 2,4-DICHLOROPHENOXYACETIC ACID (2,4-D) ON THE IMMUNE-RESPONSE IN MICE [J].
BLAKLEY, BR ;
BLAKLEY, PM .
TERATOLOGY, 1986, 33 (01) :15-20
[5]   THE EFFECT OF A COMMERCIAL 2,4-D FORMULATION ON CHEMICAL-INDUCED AND VIRAL-INDUCED TUMOR PRODUCTION IN MICE [J].
BLAKLEY, BR ;
GAGNON, JM ;
ROUSSEAUX, CG .
JOURNAL OF APPLIED TOXICOLOGY, 1992, 12 (04) :245-249
[6]   THE EFFECT OF TOPICALLY APPLIED NORMAL-BUTYLESTER OF 2,4-DICHLOROPHENOXYACETIC ACID ON THE IMMUNE-RESPONSE IN MICE [J].
BLAKLEY, BR ;
SCHIEFER, BH .
JOURNAL OF APPLIED TOXICOLOGY, 1986, 6 (04) :291-295
[7]   MALIGNANT-LYMPHOMA AND EXPOSURE TO CHEMICALS, ESPECIALLY ORGANIC-SOLVENTS, CHLOROPHENOLS AND PHENOXY ACIDS - A CASE-CONTROL STUDY [J].
HARDELL, L ;
ERIKSSON, M ;
LENNER, P ;
LUNDGREN, E .
BRITISH JOURNAL OF CANCER, 1981, 43 (02) :169-176
[8]  
HARDELL L, 1988, CANCER, V62, P652, DOI 10.1002/1097-0142(19880801)62:3<652::AID-CNCR2820620334>3.0.CO
[9]  
2-4
[10]  
HERBERMAN RB, 1977, J IMMUNOL, V119, P322