Glucagon-Like Peptide 1 Reduces Endothelial Dysfunction, Inflammation, and Oxidative Stress Induced by Both Hyperglycemia and Hypoglycemia in Type 1 Diabetes

被引:159
作者
Ceriello, Antonio [1 ,2 ,3 ]
Novials, Anna [1 ,2 ,3 ]
Ortega, Emilio [1 ,2 ,3 ]
Canivell, Silvia [1 ,2 ,3 ]
La Sala, Lucia [1 ,2 ,3 ]
Pujadas, Gemma [1 ,2 ,3 ]
Esposito, Katherine [4 ]
Giugliano, Dario [4 ]
Genovese, Stefano [5 ]
机构
[1] Hosp Clin Barcelona, Inst Invest Biomed August Pi i Sunyer, Barcelona, Spain
[2] Hosp Clin Barcelona, Ctr Invest Biomed Red Diabet, Barcelona, Spain
[3] Hosp Clin Barcelona, Enfermedades Metab Asociadas, Barcelona, Spain
[4] Univ Naples 2, Ctr Excellence Cardiovasc Dis, Div Metab Dis, Naples, Italy
[5] Grp Multimed, Dept Cardiovasc & Metab Dis, Milan, Italy
关键词
VASCULAR-DISEASE; GLYCEMIC CONTROL; INSULIN; RISK;
D O I
10.2337/dc12-2469
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVEHyperglycemia and hypoglycemia currently are considered risk factors for cardiovascular disease in type 1diabetes. Both acute hyperglycemia and hypoglycemia induce endothelial dysfunction and inflammation, raising the oxidative stress. Glucagon-like peptide 1 (GLP-1) has antioxidant properties, and evidence suggests that it protects endothelial function.RESEARCH DESIGN AND METHODSThe effect of both acute hyperglycemia and acute hypoglycemia in type 1 diabetes, with or without the simultaneous infusion of GLP-1, on oxidative stress (plasma nitrotyrosine and plasma 8-iso prostaglandin F2alpha), inflammation (soluble intercellular adhesion molecule-1 and interleukin-6), and endothelial dysfunction has been evaluated.RESULTSBoth hyperglycemia and hypoglycemia acutely induced oxidative stress, inflammation, and endothelial dysfunction. GLP-1 significantly counterbalanced these effects.CONCLUSIONSThese results suggest a protective effect of GLP-1 during both hypoglycemia and hyperglycemia in type 1 diabetes.
引用
收藏
页码:2346 / 2350
页数:5
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