Embryonic vaccines against cancer: An early history

被引：65

作者：

Brewer, Bradley G. ^{[1
,4
]}

Mitchell, Robert A. ^{[1
,2
,4
]}

Harandi, Amir ^{[1
,2
]}

Eaton, John W. ^{[1
,2
,3
]}

机构：

[1] Univ Louisville, James Graham Brown Canc Ctr, Mol Targets Grp, Louisville, KY 40202 USA

[2] Univ Louisville, Dept Med, Louisville, KY 40202 USA

[3] Univ Louisville, Dept Pharmacol Toxicol, Louisville, KY 40202 USA

[4] Univ Louisville, Dept Biochem, Louisville, KY 40202 USA

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2009年 / 86卷 / 03期

关键词：

Carcinoembryonic antigens; Anti-cancer immunity; Embryonic antigens; TUMOR-ASSOCIATED ANTIGENS; PLACENTAL ALKALINE-PHOSPHATASE; FETAL ANTIGENS; BREAST-CANCER; TRANSPLANTATION IMMUNITY; MONOCLONAL-ANTIBODY; CELL CYTOTOXICITY; PROSTATE-CANCER; RAT HEPATOMAS; EXPRESSION;

D O I：

10.1016/j.yexmp.2008.12.002

中图分类号：

R36 [病理学];

学科分类号：

100103 [病原生物学];

摘要：

Almost 100 years have passed since the seminal observations of Schone showing that vaccination of animals with fetal tissue would prevent the growth of transplantable tumors. Many subsequent reports have affirmed the general idea that immunologic rejection of transplantable tumors, as well as prevention of carcinogenesis. may be affected by vaccination with embryonic/fetal material. Following a decade of intense research on this phenomenon during similar to 1964-1974, interest appears to have waned. This earlier experimental work may be particularly pertinent in view of the rising interest in so-called cancer stem cells. We believe that further work - perhaps involving the use of embryonic stem cells as immunogens - is warranted and that the results reviewed herein support the concept that vaccination against the appearance of cancers of all kinds is a real possibility. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：192 / 197

页数：6

共 109 条

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PRODUCTION OF EMBRYONAL ALPHA-GLOBULIN BY TRANSPLANTABLE MOUSE HEPATOMAS [J].